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Voyager is looking for exceptional individuals who share our passion for developing life-changing gene therapies for severe neurological diseases.

Current Openings

Senior Research Associate, Neuroscience

Voyager Therapeutics is a clinical-stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease and Alzheimer’s Disease.

Voyager is seeking a highly motivated biologist to contribute to our research team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in in vitro and in vivo experimental methods, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental execution, and data analysis for research studies supporting cutting edge therapeutic programs and platform discovery research in neurodegenerative disease areas.  We are looking for extensive prior hands-on in with techniques such as cell culture, in vitro assay development and execution, CNS tissue preparation, qRT-PCR, western, and ELISA. This position is located in Cambridge, MA and reports to a Principal Research Scientist.

Requirements:

  • B.S. or M.S. in Biology or related discipline
  • Outstanding problem-solving skills
  • Ability to be highly productive in a fluid and fast-paced work environment
  • At least 5 years of hands-on experience with in vitro and in vivo
  • Experience with design, documentation and execution of experiments
  • Ability to independently analyze and present data to scientific team

Strongly Preferred:

  • Working knowledge of AAV, cell culture and cellular biology
  • Familiarity with molecular and cell biology methods
  • Experience with drug discovery for neurodegenerative diseases
  • Experience on cross-functional therapeutic program team
  • Experience within a start-up or small biotech environment
To apply, email careers@voyagertherapeutics.com

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Scientist, Neuroscience ( Tau )

Voyager is seeking a highly motivated neuroscientist with experience in the study of tau protein-related neurodegeneration and therapeutic discovery to contribute to our research team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in in vitro and in vivo experimental methods, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental planning, execution, and analysis of data for research studies supporting cutting edge therapeutic programs and platform discovery research in neurodegenerative disease areas.  We are looking for extensive prior hands-on expertise with in vitro assay development, cell biology, and in vitro and in vivo models of disease including tau transmission studies.  Prior hands-on experience in qRT-PCR, western, and/or ELISA methods is a plus. This position is located in Cambridge, MA.

 Requirements

  • Master’s degree with 8+ years, or Ph.D. Biology degree and 0-3 years’ experience or equivalent.
  • Extensive hands-on experience with tau and neurodegeneration related experimental models and techniques
  • Outstanding problem-solving skills
  • Ability to be highly productive in a fluid and fast-paced work environment
  • At least 3 years of hands-on experience with neurobiological in vitro techniques
  • Experience with design, documentation and execution of experiments
  • Ability to independently analyze and present data to scientific team

 

Strongly Preferred

  • Familiarity with molecular and cell biology methods
  • In vivo experience with animal models of disease
  • Experience on cross-functional therapeutic program team
  • Experience with drug discovery for neurodegenerative diseases
  • Experience within a start-up or small biotech environment
To apply, email careers@voyagertherapeutics.com

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Director, Program & Alliance Management ( Late Stage )

The Director of Program Management will play a critical role in advancing Voyager’s emerging portfolio of life-changing gene therapies for severe neurological disease.   Serving as a focal point for cross-functional collaboration, this role will bridge strategy at the corporate, portfolio, and program level to operational priorities, effective processes, and efficient execution of drug development.  This individual demonstrates a high degree of business acumen,  a highly collaborative, trust-building style, and laser-focus on driving results through effective communication, decision making, and follow-through. This position is located in Cambridge, Massachusetts.

Key Responsibilities

  • Serve as the central point of operational leadership and cross-functional coordination for Voyager’s exciting Parkinson’s Disease Program as it advances into a registration enabling Ph2/3 clinical trials
  • Drive development, evolution and execution of aggressive global development plans, including deliverables, timelines, budgets, contingency plans and stakeholder engagement
  • Partner effectively and fluidly with functional leaders and team-representatives to ensure effective program-function communication, alignment, and decision making
  • Participate as core team member in due diligence, collaboration definition, and operationalization of ex-US collaboration.
  • Ensure strong integration, relationship building, and operational execution with external Device / Delivery partners
  • Drive and instill continuous process improvement initiatives/mindset across the organization to build capability, streamline processes and improve communication and flow of information up/down across the business.
  • Develop and implement effective operational processes for tracking and reporting progress in an integrated way across timelines, resources, and key milestones.
  • Create and monitor (KPI’s) key performance indicators at the portfolio and program level, highlighting progress, risks, and mitigation options.
  • Assist with the formation and leadership of various sub teams; (Research, CMC, Pre- Clinical, Commercial) within program team umbrella to ensure alignment and efficient delivery against overall program goals
  • Foster high-performing team cultures with clear expectations, effective use of time, clear accountability, and efficient follow-up.
  • Play a highly visible and impactful role in linking Corporate Resource Planning with portfolio strategy, operational planning, and resource prioritization trade-offs
  • Partner with leaders in Commercial and Medical Affairs to ensure development and delivery of an innovative “Go-to-Market” strategy that sets the stage for a highly-successful launch Prepare and deliver presentation materials for Portfolio Management Committee, Management Team, and Board of Director meetings

 

Minimum Qualifications

  • Bachelor of Science or degree in Lifesciences required, MBA or equivalent preferred.
  • Minimum of 10 years work experience in Program/ Alliance leadership/ drug development, consulting, project or operational management roles
  • Skilled communicator, equally comfortable with written and verbal interaction across business, clinical and scientific content
  • Ability to think creatively, integrate different perspectives, and build alignment towards a shared sense of purpose.
  • Significant experience in biotech/life sciences and medical device industries highly preferred.
  • Experience working in a fast-paced, growing (start- up) environment.
  • Strong independent and Team oriented contributor
  • Highly organized and disciplined in approach.
  • Demonstrated ability to roll-up sleeves and work in a collaborative, scalable fashion.

 

 

To apply, email careers@voyagertherapeutics.com

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Associate Director, Program & Alliance Management ( Early Stage )

The Director of Program Management will play a critical role in advancing Voyager’s emerging portfolio of life-changing gene therapies for severe neurological disease.   Serving as a focal point for cross-functional and scientific collaboration, this role will bridge strategy at the corporate, portfolio, and program level to operational priorities, effective processes, and efficient execution of drug development.  This individual demonstrates a high degree of business and scientific acumen, a highly collaborative, trust-building style, and laser-focus on driving results through effective communication, decision making, and follow-through. This position is located in Cambridge, MA.

Key Responsibilities

  • Drive advancement of Voyager’s Early Stage Pipeline Programs and help accelerate differentiation and translation of platform capabilities into new programs and partnerships
  • Lead multiple early-stage Program Teams in developing appropriately ambitious development plans, including articulation of Target and Minimum Product Profiles, timelines, budgets, and overall value proposition
  • Partner effectively with senior leaders in Research, Clinical Development, Technical Operations, and Regulatory to ensure effective program-functional communication and alignment
  • Work closely with Commercial, Business Development, and Investor Relations to translate scientific and clinical potential into compelling product profile concepts supporting engagement with investors and potential partners.
  • Play a highly visible and impactful role in linking R&D Resource Planning with portfolio strategy, operational planning, and resource prioritization trade-offs
  • Serve as Alliance Manager for partnered programs, ensuring seamless communication and effective discussions/decisions as needed
  • Develop and implement effective operational processes for tracking and reporting progress in an integrated way across timelines, resources, and key milestones.
  • Create and monitor (KPI’s) key performance indicators at the portfolio and program level, highlighting progress, risks, and mitigation options.
  • Assist with the formation and leadership of various sub teams; (Research, CMC, Pre- Clinical, Commercial) within program team umbrella to ensure alignment and efficient delivery against overall program goals
  • Foster high-performing team cultures with clear expectations, effective use of time, clear accountability, and efficient follow-up.
  • Prepare and deliver presentation materials for Portfolio Management Committee, Management Team, and Board of Director meetings

 

Minimum Qualifications

  • Bachelor of Science or degree in Lifesciences required, Master’s/ Ph.D preferred.
  • Minimum of 10 years work experience in Program/ Alliance leadership/ drug development, consulting, project or operational management roles
  • Skilled communicator, equally comfortable with written and verbal interaction across business, clinical and scientific content
  • Ability to think creatively, integrate different perspectives, and build alignment towards a shared sense of purpose.
  • Significant experience in biotech/life sciences and medical device industries highly preferred.
  • Experience working in a fast-paced, growing (start- up) environment.
  • Strong independent and Team oriented contributor
  • Highly organized and disciplined in approach.
  • Demonstrated ability to roll-up sleeves and work in a collaborative, scalable fashion.

 

To apply, email careers@voyagertherapeutics.com

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Vice President, Regulatory Affairs

Reporting to the Senior Vice President of Regulatory Affairs, the Vice President of Regulatory Affairs will work closely with Regulatory staff and cross-functional teams to develop and implement regulatory strategy and summarize scientific data and submission packages to US and international regulatory agencies. This individual will be responsible for filing and supervising submission of multiple INDs and determining the strategy for multiple projects including broad-based applications including PD, ALS, Huntington’s disease, Friedreich’s ataxia, Alzheimer’s disease, chronic pain and vectorized antibodies. Responsibilities include actively leading the development and implementation of regulatory strategy for specific projects including identifying and assessing regulatory risks and pathways for expedited development and timelines, serving as the regulatory representative or supervisor on project teams, active involvement in writing/review of regulatory submissions,  interfacing with Health authorities, coordinating all aspects of regulatory submissions and proactively keeping updated on regulatory requirements and expedited approaches worldwide. The incumbent will require demonstrated leadership capabilities in the following areas; lead and manage BLA submissions, self-motivated/ independent, manage and mentor staff, work collaboratively with Senior Management, as needed, and when called upon, collaboration partners in a fast-paced evolving gene therapy biotechnology environment. This position is located in Cambridge, MA.

Responsibilities

 

  • Lead and assist the SVP of Regulatory to drive project teams in early research and late stage clinical development for neurological diseases.
  • Partner with cross-functional organizations; Clinical Development and R&D areas to design and execute an effective global regulatory strategy in alignment with the overall development plan and corporate goals.
  • Present the overall Voyager Regulatory strategy and work closely with Alliance partners in Regulatory Affairs and other disciplines to prepare and execute global development programs addressing the needs of each partner.
  • Lead, supervise and develop staff in the planning, preparation (including authoring where relevant) and delivery of routine and complex submissions throughout the product’s life cycle, including briefing documents, INDs, and various expedited designation requests including breakthrough, regenerative medicine advanced therapy, orphan drug, fast track and rare pediatric disease where appropriate.
  • Lead the planning, strategy, content and execution of BLA filing and follow through to approval
  • Identify potential regulatory risks to the strategic/operational plans, and propose options to mitigate risks.
  • Prepare the team and lead negotiations with FDA and other health agencies.
  • Provide regulatory due diligence as required.
  • Supervise and mentor direct reports who will be managing other programs.

Minimum Qualifications

  • Bachelor of Science Degree; PharmD, PhD or MD degree preferred.
  • At least 15 years of experience working in Regulatory Affairs; ideally 10 plus years in the biotech industry (gene therapy, monoclonal antibodies, vaccines, blood products, and/or cell products). Regulatory device strategy and experience, a plus.
  • Sound knowledge and experience in Regulatory Affairs and associated requirements, plus pharmaceutical industry experience in clinical trial and drug development work with a record of successful drug development through product approval in the US, EU, Asia.
  • Thorough knowledge of the drug development process including all expedited pathways and orphan drug designations, INDs, CTAs BLAs and MAAs.
  • Experience in interfacing with FDA and other Health authorities. Gene therapy experience a plus.

Skills /Competencies

  • Deep knowledge and understanding of global regulatory requirements and environment.
  • Demonstrated strategic thinking and implementation in overall drug development.
  • Must be able and willing to work diligently in a high-visibility, fast-paced environment and exhibit passion for patients with debilitating neurological diseases.
  • Must be detail-oriented, and possess good analytical and problem-solving skills.
  • Excellent verbal and written communication skills and strong interpersonal skills.
  • Ability to work independently with minimal supervision, and to take ownership and responsibility.
  • Ability to manage and develop Regulatory staff members who are supervised and work cooperatively with teams including alliance partners and influence cross-functionally.
  • Results focused and able to work under pressure and to set and meet deadlines.
  • Confident with the professional competence to win respect and gain credibility at all levels within and outside the company; capable of representing the company externally.
  • Demonstrated ability for innovative and flexible strategies.
  • Adaptable and self-motivated, able to prioritize effectively with strong problem solving and planning abilities.
  • Complete alignment with Voyager’s Core Values

 

 

 

To apply, email careers@voyagertherapeutics.com

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Senior Engineer, Manufacturing Sciences

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes is central for establishing successful gene therapy applications.

Voyager is seeking a Senior Engineer,  Manufacturing Sciences who will manage multiple CMC projects with CMOs. This role coordinates, supports, and assists cross-functional interaction among the internal development team (process development, analytical development and Quality teams) and the CMO, particularly being responsible for the interaction with the CMO project managers.  S/he develops CMC project budgets, timelines, and risk assessments, and is responsible for performance against these parameters.  The individual actively monitors and reports on project status, the financial status of the work within the CMOs, interacts regularly with the program core team and other functions as necessary to communicate the risks and decisions required and highlights assumptions associated with CMC timelines.

Responsibilities

  • Develop external CMC project plans for existing and envisioned projects, with input from other Technical Operations functions (process development, analytical development, and Quality)
  • As member of CMC team meeting, provide estimates for the resources, cost, timeline tasks, and alternative options to accomplish desired schedule
  • Coordinate the interaction of the CMC cross-functional projects among Voyager personnel, and between Voyager and the CMOs.
  • Work closely with CMOs used to produce GMP material, using site visits and frequent communication with CMO team members to update status of CMC project
  • Interact with program core teams to ensure alignment of CMC plan with overall program strategy, and the requirements of pre-clinical and clinical teams
  • Monitor scope, milestones, dependencies, and costs associated with CMO project and the timelines for CMO deliverables.
  • Drive projects through project goals to ensure compliance to defined schedule.
  • Interact with finance to appraise them of changes in cost and assignment of work orders to specific functions and tasks
  • Create and maintain comprehensive risk management plan for product production
  • Working with the CMC team, provide effective mitigation and escalation strategies for project risks and CMC issues.
  • Manage short and long-term project commitments to supply of drug substance and drug product and communicate levels to internal project teams.
  • Develop and update standard external CMC plans, based on process and historical data, to provide guidance on cost and FTEs required to manage and produce GMP material for new Development projects
  • Manage transition of CMC project from research to development and from early stage to late stage production at a CMO.
  • Strengthen and maintain relationships with key Voyager project team employees and outside vendors and suppliers of CMC services.
  • Assist in coordinating key vendor and supplier evaluations, particularly those supplying services related to raw material supply, product manufacturing, release, storage, and characterization.
  • Ensure project teams adhere to company and departmental policies, procedures, and standards for storage of data related to product production.

Qualifications

  • Minimum PhD in Engineering with 5+ experience with processes to make biologics, preferably within a smaller pharmaceutical company, or BS\MS degree in Engineering with 10+ years of experience with processes making biologics
  • Experience with planning and managing CMC aspects of biopharmaceutical development
  • Experience in process development and process transfer, focused on biologics or proteins
  • Experience as person in plant (PIP) for production of biologics
  • Ability to travel ( U.S./ Int’l ) 25-50% of time, particularly when production campaigns are being done
  • Has demonstrated the ability to organize external resources to maximize quality and efficiency. Maintains an overview of the entire process when planning a project, setting both short and long-term goals.
  • Works effectively aligning actions to project targets, milestones, and priorities.
  • Excellent communication skills, with the ability to provide clear and audience-focused descriptions of CMC tasks and issues, and proposed solutions to schedule challenges, all done in an open and honest manner.
  • Able to achieve goals in a timely manner, despite obstacles, by prioritizing tasks and building in contingency planning. Results oriented and demonstrates a focus on getting (business) results.
  • Demonstrated ability to facilitate project team meetings, enhance cross-functional communication, support decision making, influence outcomes, and ensure alignment among internal (and sometimes external) stakeholders.
  • Familiar with current issues and Regulatory requirements related to manufacturing using single use equipment for drug substance and drug product production
  • Familiar with trends and developments in the gene therapy field and able to translate those developments into specific business advantages and risks related to production.
  • Proficiency with Microsoft Office suite (e.g. Word, Excel, PowerPoint, Project, Outlook).
To apply, email careers@voyagertherapeutics.com

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Associate Director CMC Portfolio Management

Voyager is seeking an Associate Director of CMC Portfolio Management who will proactively manage multiple CMC projects.

This role coordinates, supports, and assists cross-functional interaction among the internal TechOps functions (Process Development, Analytical Development, Manufacturing, Quality, Supply Chain) and broader functions within Voyager, namely Program Management, Research, Clinical, and Regulatory, as well as external project partners.

S/he develops CMC project budgets, timelines, and risk assessments and is responsible for performance against these parameters. The individual actively monitors, owns and reports on timelines and project status, and financial status of the work. Interacts regularly with the program core team and other functions as necessary to communicate the risks and decisions required and highlights assumptions associated with CMC timelines. The individual will be also responsible to develop and maintain resource models (e.g. FTE burn rate) across all TechOps functions, being able to generate utilization data for each department to assist in short and long-term resource planning.

This position reports to the Chief Technical Operations Officer and is located on-site in Cambridge Massachusetts.

Responsibilities

  • Coordinate the interaction of the CMC cross-functional projects or programs among Voyager personnel and manage CMC timelines.
  • Develop CMC project plans for multiple existing and envisioned projects.
  • Create, manage and monitoring scope, milestones, dependencies, risks, and costs associated with each project
  • Interact with program core teams to ensure alignment of CMC with overall program strategy
  • Interact with finance to appraise them of changes in risks, cost and assignment of work orders to specific functions and tasks
  • Maintain these inputs and create comprehensive risk management plan against these risks and provide that information to the team and senior management
  • Develop a standard CMC plan for Voyager to provide guidance on cost and FTEs requirements related to Research projects which move into Development
  • Create project communication tools, such as project dashboards, CMC team meeting minutes and summaries, resource and time line plans and staffing to accomplish these plans. Responsible to communicate status of Voyager’s CMC portfolio.
  • Solidify and maintain relationships with key customers (within and outside Voyager).
  • Ensure projects follow company and departmental policies, procedures, and standards, particularly focused on storage of data related to projects.
  • Identify and highlight project risks and issues related to tasks and timelines and escalate appropriately. Working with the CMC team, provide effective mitigation and escalation strategies for projects to address risks and issues.
  • Follow project governance structures and processes to drive and manage the project.
  • Manage implementation of project management methodology and governance tools, particularly defined project goals for transition from research to development and from early stage to late stage. Drive projects through project goals to ensure compliance to defined schedule and staffing goals
  • Lead regular CMC project and program reviews with Program Managers and key stakeholders.
  • Develop and maintain resource models (e.g. FTE burn rate) across all TechOps functions, being able to generate utilization data for each department

Qualifications

  • Minimum Bachelor’s degree in Chemical Engineering, Masters or PhD preferred.
  • D. 7+ years BS/MS 10+ years of relevant experience in Biologics, Vaccines or Gene Therapy CMC development or manufacturing.
  • Experience with planning and managing all phases of biopharmaceutical development
  • Experience in managing projects focused on biologics or proteins within smaller company environment
  • Familiarity with trends and developments in that field and is able to translate those to the specific business context.
  • Excellent communication skills
  • Demonstrated ability to facilitate project team meetings, enhance cross-functional communication, support decision making, influence outcomes, and ensure alignment among internal (and sometimes external) stakeholders.
  • Highly skilled and proficient in the use of Project Management tools. PMP certification preferred.
  • Results oriented and demonstrates a focus on getting (business) results and works effectively towards targets, milestones and priorities.
  • Has demonstrated the ability to organize resources to maximize quality and efficiency. Maintains an overview of the entire process when planning a project, setting both short and long-term goals.
  • Able to achieve goals in a timely manner despite obstacles by organizing and prioritizing tasks and building contingency. Beating targets, going beyond what was set, or defining own higher goals.
  • Proficiency with Microsoft Office suite (e.g. Word, Excel, PowerPoint, Project, Outlook).

 

 

To apply, email careers@voyagertherapeutics.com

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Research Associate, Process Development (Downstream/Formulation Focus)

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes is central for establishing successful gene therapy applications.  Voyager is seeking a highly motivated Research Associate to join the Process Development Group with a focus on downstream purification and formulation.  The qualified candidate will assist with and/or individually carry out chromatographic purifications, various filtration operations, formulation studies for Voyager’s various rAAV products, and conduct stability studies.  Work activities will also include following / preparing protocols, SOPs and final study reports, and general lab operations.  The ability to independently organize, design, carryout and analyze data and report the results of their work in a concise and well documented manner are important aspects of the position. This position is located in Cambridge, MA.

Responsibilities

  • Perform benchtop and preparative separations of rAAV particles from an insect cell line using various filtration, TFF, centrifugation and chromatographic techniques
  • Develop protocols for viral capsid purification using column chromatography / Akta protein purification systems
  • Complete concentrations and diafiltrations using hollow fibers and small plate and frame TFF systems
  • Carryout Pmax and Vmax studies for depth and sterile filtration development
  • Make reagents and solutions required for production protocols
  • Maintain and update databases for reagents
  • Execute studies for rAAV product formulation development
  • Carry out stability studies for DS/DP/IP pools
  • Write various experimental reports, SOPs, batch records, technology transfer documents and participate in authoring relevant regulatory documents
  • Assist with the production of nonclinical materials at Voyager

Qualifications

  •  Bachelor’s degree in chemical engineering, biology, biochemistry, chemistry, biotechnology, or related fields
  • A minimum of 1 year of downstream purification and/or formulation experience is required; preferred that experience is in either an industrial, process development or pharmaceutical co-op setting
  • Strong writing, verbal, and organizational skills
  • Highly motivated and a self-driven individual with the ability to quickly learn and work in a fast-paced, start-up environment
  • Previous experience working with the downstream purification or formulation of protein biologics, vaccines, or rAAV viral vectors desired

 

Ref # 18TOCM006

To apply, email careers@voyagertherapeutics.com

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Scientist/Engineer, Process Development (Formulation Focus)

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes with stable DS/DP formulations is central for establishing successful gene therapy applications.  Voyager is seeking a highly motivated Scientist to join the Process Development Group with a focus on formulation.  The qualified candidate will be a leader within the group with a strong background and expertise in the formulation of biologics.  Primary responsibilities will include carrying out formulation development and feasibility activities for pre-clinical and cGMP grade rAAV products, participating in and leading technology transfer activities to internal parties and assorted CROs/CMOs, carrying out device compatibility studies, and finally supporting cGMP manufacture person in plant activities where needed.  The ability to independently organize and design experiments, analyze data and report the results of their and other’s work in a concise and well documented manner, and to take the initiative to successfully drive Voyager’s projects and manufacturing process are all important aspects of the position.  

Responsibilities

  • Design and execute studies for rAAV product formulation development, process scale-up and technology transfer to CMOs
  • Develop and optimize TFF steps for final product formulation
  • Assist with and carryout downstream purification steps and optimization where needed
  • Design and execute device capability studies with various rAAV products and device materials
  • Plan and carry out long term DS/DP stability studies under various conditions
  • Develop scaled down, high-throughput methods and protocols for formulation evaluation and development
  • Work with analytical development to develop and implement stability indicating assays
  • Generate, manage, and maintain critical methods and data in a highly organized manner
  • Assist with the production of nonclinical materials
  • Write various experimental reports, SOPs, batch records, technology transfer documents and participate in authoring relevant regulatory documents
  • Provide support for and lead the transfer of developed protocols and formulation processes to internal and external manufacturing parties
  • Lead innovation, development and optimization of the Voyager platform manufacturing process and formulations
  • Lead as Voyager point person for and maintain various external relationships with partners, vendors and CMOs/CROs
  • Engage/ Lead Process Development group’s IP, conference and publication strategy

Qualifications

  • Degree in chemical engineering, biology, biochemistry, chemistry, biotechnology, or related fields
  • PhD degree in relevant subject matter with 3+ years industrial experience in formulation / process development
  • Previous experience working with protein biologics or vaccines is a must, prior experience working with rAAV products desired
  • Proficient in miniaturized formulation screening techniques, TFF unit operations and biochemical / biophysical / nanoparticle analytical methods
  • Strong desire to learn multiple new techniques and willingness to work as part of a larger team
  • Significant attention to detail and accuracy in developing, reviewing and following protocols, SOPs, batch records and technology transfer documents
  • Ability to be highly productive in a fluid, fast-paced and teamwork oriented environment

 

Ref# 18TO-CM005

To apply, email careers@voyagertherapeutics.com

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Senior Research Associate / Research Associate, Process Development (Downstream Focus)

Voyager is seeking a highly motivated Senior Research Associate / Research Associate to join the Process Development group with a focus on downstream purification.  The qualified candidate will carry out process development activities for the manufacture of pre-clinical and cGMP grade rAAV products.  In addition, the candidate will also participate in internal production activities, writing appropriate documents, assisting with technology transfer activities, and participating in cGMP manufacture person in plant activities. The ability to independently organize and design experiments, analyze data and report the results of their work in a concise and well documented manner are important aspects of the position. This position is located in Cambridge, MA.

Responsibilities

  • Perform benchtop and preparative separations of rAAV particles from an insect cell line using various filtration, TFF, centrifugation and chromatographic techniques
  • Develop protocols for viral capsid purification using column chromatography / Akta protein purification systems
  • Complete concentrations and diafiltrations using hollow fibers and small plate and frame TFF systems
  • Carryout Pmax and Vmax studies for depth and sterile filtration development
  • Make reagents and solutions required for production protocols
  • Maintain and update databases for reagents
  • Write various experimental reports, SOPs, batch records, technology transfer documents and participate in authoring relevant regulatory documents
  • Assist with the production of nonclinical materials at Voyager

Qualifications

  • Bachelor’s or Master’s degree in chemical engineering, biology, biochemistry, chemistry, biotechnology, and related fields
  • Minimum B.S. degree with 3+ years of relevant industrial experience or a M.S. degree in relevant subject matter (e.g. chromatography/filtration of biologics)
  • Previous experience working with protein biologics or vaccines is a must, prior experience working with AAV and/or in a process development group is desired
  • Experience with virus purification or protein purification, including the use of Akta systems, UF\DF systems, and cell filtration devices
  • Strong desire to learn multiple new techniques and willingness to provide support to more senior research personnel as required
  • Significant attention to detail and accuracy in developing and following protocols
  • Ability to be highly productive in a fluid, fast-paced and teamwork environment

 

Ref# 18TO-CM 004

To apply, email careers@voyagertherapeutics.com

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Senior Research Associate/ Research Associate, Process Development (Upstream Focus)

Voyager is seeking a highly motivated Sr. Research Associate / Research Associate to join the Process Development group with a focus on upstream production.  The qualified candidate will carry out process development activities for the manufacture of pre-clinical and cGMP grade rAAV products.  In addition, the candidate will also participate in internal production activities, writing appropriate documents, assisting with technology transfer activities, and participating in cGMP manufacture person in plant activities. The ability to independently organize and design experiments, analyze data and report the results of their work in a concise and well documented manner are important aspects of the position. This position is located in Cambridge, MA.

Responsibilities

  • Design, development, and optimization of cell growth, transfection, viral infection, and rAAV manufacturing using shake flasks, small-scale and large-scale bioreactors in an Sf9 / baculovirus production system
  • Assemble, sterilize, prepare, and maintain bioreactors, ancillary materials and equipment for cell culture, viral infection and harvest experiments
  • Perform monitoring of cell viability and growth, cell culture metabolites, and other measurements from cultures
  • Develop protocols for viral genome / capsid production in shake flasks, wave bioreactors and stirred tank bioreactors
  • Generate, manage, and maintain critical methods and data in a highly organized manner
  • Assist with and lead the production of nonclinical materials at Voyager
  • Write various experimental reports, SOPs, batch records, technology transfer documents and participate in authoring relevant regulatory documents
  • Provide support for and lead the transfer of developed protocols and upstream processes to internal and external manufacturing parties

Qualifications

  •  Bachelor’s or Master’s degree in chemical engineering, biology, biochemistry, chemistry, biotechnology, and related fields
  • Minimum B.S. degree with 3+ years of relevant industrial experience or a M.S. degree in relevant subject matter (e.g. cell culture production of biologics)
  • Previous experience working with protein biologics or vaccines is a must, prior experience working with AAV and/or in a process development group is desired
  • Technical proficiency and experience for aspects of cell line growth optimization and production of biological products using bioreactors is required
  • Strong desire to learn multiple new techniques and willingness to provide support to more senior research personnel as required
  • Significant attention to detail and accuracy in developing and following protocols
  • Ability to be highly productive in a fluid, fast-paced and teamwork environment

 

 

Ref# 18TO-CM 003

To apply, email careers@voyagertherapeutics.com

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Voyager is seeking a highly motivated Senior Scientist and/or Engineer to join the Process Development Group with a focus on upstream production.  The qualified candidate will be a leader within the group with a strong background and expertise in cell culture manufacturing of biologics. 

Primary responsibilities will include carrying out upstream process development activities for the manufacture of pre-clinical and cGMP grade rAAV products, participating in and leading internal productions, writing appropriate documents and carrying out technology transfer to assorted CMOs, and finally participating in cGMP manufacture person in plant activities.  The ability to independently organize and design experiments, analyze data and report the results of their and other’s work in a concise and well documented manner, and to take the initiative to successfully drive Voyager’s projects and manufacturing process are all important aspects of the position.  

Responsibilities

  • Design, development, and optimization of cell growth, transfection, viral infection, and rAAV manufacturing using shake flasks, small-scale and large-scale bioreactors in an Sf9 / baculovirus production system
  • Assemble, sterilize, prepare, and maintain bioreactors, ancillary materials and equipment for cell culture, viral infection and harvest experiments
  • Perform monitoring of cell viability and growth, cell culture metabolites, and other measurements from cultures
  • Develop protocols for viral genome / capsid production in shake flasks, wave bioreactors and stirred tank bioreactors
  • Generate, manage, and maintain critical methods and data in a highly organized manner
  • Assist with and lead the production of nonclinical materials at Voyager
  • Write various experimental reports, SOPs, batch records, technology transfer documents and participate in authoring relevant regulatory documents
  • Provide support for and lead the transfer of developed protocols and upstream processes to internal and external manufacturing parties
  • Lead innovation, development and optimization of the Voyager upstream platform manufacturing process
  • Lead as Voyager point person for and maintain various external relationships with partners, vendors and CMOs/CROs
  • Highly engaged/ involved, leading the Process Development group’s IP, conference and publication strategy

Qualifications

  • Degree in chemical engineering, biology, biochemistry, chemistry, biotechnology, or related fields
  • PhD degree in relevant subject matter (e.g. cell culture production of biologics) with 5+ years industrial experience in process development
  • Previous experience working with protein biologics or vaccines is a must, prior experience working with rAAV products desired
  • Proficient with aseptic techniques and the use of shake flasks, wave based bioreactors, and stirred tank bioreactors at various scales
  • Strong desire to learn multiple new techniques and willingness to work as part of and help lead a larger team
  • Significant attention to detail and accuracy in developing, reviewing and following protocols, SOPs, batch records and technology transfer documents
  • Ability to be highly productive in a fluid, fast-paced and teamwork oriented environment
  • Prior experience with tech transferring to a cGMP facility is a must, prior experience working with external CMOs desired
  • Prior experience managing a team, co-ops or direct reports is desired

 

Ref# 18TO-CM002

To apply, email careers@voyagertherapeutics.com

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Senior Scientist/Engineer, Process Development (Downstream Focus)

Voyager is seeking a highly motivated Senior Scientist to join the Process Development Group with a focus on downstream purification. 

The qualified candidate will be a leader within the group with a strong background and expertise in downstream manufacturing of biologics.  Primary responsibilities will include carrying out downstream process development activities for the manufacture of pre-clinical and cGMP grade rAAV products, participating in and leading internal productions, writing appropriate documents and carrying out technology transfer to assorted CMOs, and finally participating in cGMP manufacture person in plant activities.  The ability to independently organize and design experiments, analyze data and report the results of their and other’s work in a concise and well documented manner, and to take the initiative to successfully drive Voyager’s projects and manufacturing process are all important aspects of the position.  

 Responsibilities

  • Perform benchtop and preparative separations of rAAV particles from an insect cell line using various filtration, TFF, centrifugation and chromatographic techniques
  • Develop protocols for viral capsid purification using column chromatography / Akta protein purification systems
  • Complete concentrations and diafiltrations using hollow fibers and small plate and frame TFF systems
  • Carry-out Pmax and Vmax studies for depth and sterile filtration development
  • Determine recipes of and make reagents / solutions required for production
  • Perform viral removal / inactivation steps and qualification studies
  • Provide support for and lead the transfer of developed protocols and downstream processes to internal and external manufacturing parties
  • Write various experimental reports, SOPs, batch records, technology transfer documents and participate in authoring relevant regulatory documents
  • Assist with and lead the production of nonclinical materials at Voyager
  • Lead innovation, development and optimization of the Voyager downstream platform manufacturing process
  • Leas as Voyager point person for and maintain various external relationships with partners, vendors and CMOs/CROs
  • Interact/ high level of engagement leading Process Development group’s IP, conference and publication strategy

Qualifications

  • Degree in chemical engineering, biology, biochemistry, chemistry, biotechnology, or related fields
  • PhD degree in relevant subject matter (e.g. chromatography/filtration of biologics) with 5+ years industrial experience in process development
  • Previous experience working with protein biologics or vaccines is a must, prior experience working with rAAV products desired
  • Proficient with the use of Akta and other chromatography systems, UF\DF systems, and cell filtration devices
  • Strong desire to learn multiple new techniques and willingness to work as part of and help lead a larger team
  • Significant attention to detail and accuracy in developing, reviewing and following protocols, SOPs, batch records and technology transfer documents
  • Ability to be highly productive in a fluid, fast-paced and teamwork oriented environment
  • Prior experience with tech transferring to a cGMP facility is a must, prior experience working with external CMOs desired
  • Prior experience managing a team, co-ops or direct reports is desired

 

Ref # 18TO-CM001

To apply, email careers@voyagertherapeutics.com

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Voyager is seeking a highly motivated scientist to contribute to the Analytical Development group. The qualified candidate will participate in development, qualification, and transfer of new state-of-the-art analytical methods to be used for characterization and release of Voyager’s products. This role is currently an individual contributor but may expand to having direct reports in the future. This position is located in Cambridge, MA.

Responsibilities

  • Develop analytical methodologies and strategies needed to progress products in the pipeline including method development, process support, formulation and stability support, product characterization and method qualifications
  • Develop cell-based bioassays for AAV viral vector products
  • Revise, review, and author assay standard operating procedures
  • Act as subject matter expert in providing analysis and data interpretation both internally and externally with CMO’s/CRO’s
  • Manage and participate in tech transfer of analytical methods to CMO’s/CRO’s
  • Develop and deliver scientific presentations, prepare clear and concise technical reports, participate in project teams, and contribute to regulatory filings

 

Minimum Qualifications

  • PhD or Masters in analytical chemistry, biotech, biochemistry or a related field
  • Minimum 5+ (with a PhD) or 15+ years (with an MS) of analytical development experience in industry
  • In-practice knowledge of the ICH for assay qualification and validation
  • Demonstrated ability to efficiently develop an assay from conception to a qualified/pre-validated state
  • Experience with bioassay development for biologics/vaccines/gene therapy.
  • Candidate should be detail-oriented, self-motivated, goal driven, and should be able to work effectively on teams to progress projects. The candidate’s ability to take initiative and manage projects is highly desirable.
  • Demonstrated ability to multi-task and be highly productive in a fluid and fast-paced environment
  • Ability to write and communicate effectively with cross-functional teams

 

Preferred Qualifications

  • Experience in developing methods and performing the analysis of AAV or other similar viral vectors
  • Developing cell-based bioassays for gene therapy viral vectors
  • Knowledge and interest in laboratory and equipment automation
  • Industrial experience and an understanding of the biologics drug development process is desired.
To apply, email careers@voyagertherapeutics.com

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Voyager is seeking a highly motivated Research Associate for a position within the analytical development group. The qualified candidate will maintain adherent cell culture and plate cells for bioassays using aseptic conditions. The candidate will also perform analysis of process development and pre-clinical grade materials. After product testing, the candidate will be responsible for data analysis as well as reporting of data. Responsibilities include, but not limited to the following. This position is located in Cambridge, MA.

Responsbilities

  • Maintain cell culture and plate cells for bioassays under aseptic conditions
  • Independently, conduct assays on in-process and final products
  • Perform routine assays on a weekly basis to determine product quality
  • Analyze data and record results into ELN/LIMS in a timely manner
  • Formulation and testing of buffers and materials needed for routine assays
  • Perform both qualitative and quantitative analysis of proteins (ELISA, Western blot, silver stain/PAGE) and DNA (qPCR, agarose gel electrophoresis)

Qualifications

  • BS in Biochemistry/Biology/Chemistry/Virology or a related field
  • 1-3 years of relevant experience in (Biotech/Biopharma) industry
  • Experience testing AAV or similar gene therapy viral vectors highly preferred
  • Experience with aseptic adherent mammalian cell culture maintenance is important for qualifying for this position
  • Strong desire to learn multiple techniques and willingness to provide support as required
  • Significant attention to detail and accuracy in following protocols
  • Demonstrated ability to be highly productive in a fluid, fast-paced and team work environment
To apply, email careers@voyagertherapeutics.com

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The Director of Financial Planning & Analysis (FP&A) will provide key, hands-on strategic, business and financial leadership throughout the Voyager organization. This high visibility role will offer demonstrated experience and execution with financial analysis, modeling and strategic planning.  The successful candidate will be a seasoned professional who can collaborate and partner across Voyager’s fast – paced organization including the executive team, department owners and program stakeholders.

This newly created, on-site role is located in Cambridge, Massachusetts and reports to the Vice President of Finance.

Responsibilities:

  • Lead Voyager’s annual budgeting and quarterly forecasting process
  • Drive preparation and delivery of financial management reporting with clear communication around business drivers and future implications
  • Partner and collaborate across multiple cross-functional departments, including Executive Leadership to provide financial support/guidance necessary to drive alignment and sound decision making
  • Drive analytics and modeling for potential business development activities, including valuations and scenario planning
  • Create and monitor (KPI’s) key performance indicators, highlighting trends and analyzing causes of unexpected variance
  • Analyze financial information and reports to provide timely financial recommendations to management for decision making purposes
  • Conduct complex modeling, analysis with options, to influence internal business partners’ decisions around strategic initiatives
  • Drive organizational focus and establishment of long-term planning
  • Partner with the Accounting team on monthly, quarterly and annual closing and reporting processes
  • Enhance the use of the budgeting and analysis tools
  • Drive continuous improvement within the finance organization to streamline processes and improve communication and flow of information to the business
  • Prepare presentation materials for Board of Director and Management Team meetings

Qualifications:

  • Bachelor’s degree in Finance or Accounting required, MBA or equivalent preferred
  • Minimum of 10 years work experience in accounting and/or financial planning and analysis with significant experience in biotech/life sciences
  • Experience with successful in a fast-paced, growing (start- up) environment, ideal
  • Strong independent and Team oriented contributor
  • Provide highest standards of accuracy and precision; highly organized
  • Articulate with excellent verbal and written communication skills
  • Ability to think creatively, highly-driven and self-motivated
  • Demonstrated ability to roll-up sleeves and work in a collaborative, scalable fashion.
  • Advanced experience with Microsoft Office Suite, to include Power point.

 

Thank you, no agency resumes/referrals or services will be engaged at this time

 

 

To apply, email careers@voyagertherapeutics.com

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The Vice President, Corporate Counsel will report to the Chief Financial Officer, and will provide leadership, management and guidance on legal matters and risk management for Voyager. This key role will coordinate legal advice in the areas including business development/ licensing, corporate law, contracts, SEC, litigation, data privacy, regulatory/clinical law and intellectual property. This executive will have significant impact on the development of corporate programs, policies and actions, by advising on legal ramifications, requirements and legal actions critical to effective strategic business decisions. The VP, Corporate Counsel will work in close partnership with the CFO, and will frequently interact with CEO, executive leadership team and our Board of Directors. This newly created role will provide hands-on expertise as well as coordinate with specialized outside counsel as needed.

Responsibilities

  • Manages current team of Contracts Manager, plus multiple external counsel relationships
  • Provide advice and direction to managers and employees on operational issues including, but not limited to: IP protection, legal risk, and regulatory compliance.
  • Analyze, facilitate, negotiate and draft complex transactions including but not limited to licensing agreements, sponsored research agreements, etc.
  • Oversees all contract work, including, but not limited to, drafting/reviewing/negotiating services agreements, vendor contracts, licensing agreements, leases, clinical trial agreements , sponsored research contracts, consulting agreements, and non-disclosure agreements
  • Responsible for training the organization on contracts practices, negotiation, compliance, intellectual property protection, and other contracts, legal and compliance topics.
  • Regulatory work, including researching and interpreting federal and state laws, regulations, interpretive guidelines, advisory opinions and court cases for corporate and healthcare issues.
  • Develop, review and/or revise corporate policies and procedures.
  • Act as corporate secretary, including documenting board and committee minutes and maintaining governance and contracts recordkeeping systems.
  • Review inquiries/complaints from state and federal administrative, regulatory and other governmental or accreditation agencies, perform necessary research of the law and internal practices, coordinate, draft, and negotiate the response and/or reviewing responses to the government agency.
  • Perform due diligence related activities in assigned areas in connection with business development activities.
  • Draft and present training programs on legal topics.

Qualifications

  • JD from an accredited law school, with membership in good standing of the bar in the Commonwealth of Massachusetts.
  • 10+ years of legal experience, with at least 5 in biotech/life sciences industry
  • Skilled communicator who can concisely describe and articulate key legal issues and options.
  • Strong organizational skills, with demonstrated ability to manage a broad and varied workload and prioritize effectively
  • Strong results-orientation, with excellent strategic thinking abilities and demonstrated ability to advise on current needs and emerging considerations.
  • Experienced in selecting and managing outside counsel
  • Experience in training, educating and advising executives, employees, key business partners and others on key legal topics required
  • Ability to work independently and as a team player

* Voyager is not accepting agencies, search firms or external candidates for this role*

To apply, email careers@voyagertherapeutics.com

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To apply or learn more about career opportunities at Voyager Therapeutics, please email careers@voyagertherapeutics.com.

Note to Employment Agencies: Please do not forward agency resumes. Voyager Therapeutics is not responsible for any fees related to resumes that are unsolicited and out of executed contracts.

Voyager Therapeutics will only accept job applications from candidates who are properly documented with authorization to work in the United States.

Equal Opportunity Employer M/F/D/V