Research Associate, Antibody Discovery

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Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Huntington’s disease, Friedreich’s ataxia, Alzheimer’s Disease and neuropathic pain.

The Antibody Platform group at Voyager Therapeutics is looking for a highly motivated individual experienced in antibody discovery and engineering, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment.  The individual will be responsible for activities that include culture and cloning of hybridomas for monoclonal antibody production and characterization, screening of hybridoma clones, antibody V gene sequencing, and recombinant antibody expression, purification, and characterization.  This position is located in Cambridge, MA.

Experience/Qualifications:

  • BA/BS or MS with a strong background in protein biochemistry, molecular biology, cell biology, or related field (with 2+ years of relevant laboratory experience in a biotech setting)
  • Substantial hands-on experience with protein binding assays (ForteBio Octet, Biacore, ELISA, flow cytometry) and developability assessment (CIC, AC-SINS, BV ELISA) preferred
  • Significant hands-on experience with transient and stable expression of proteins in HEK293 and CHO cells
  • Hands-on experience in antibody and/or protein purification (affinity, ion exchange, SEC) methodology
  • Experience with antibody sequence isolation, repertoire analysis, and V region classification is highly desired
  • Excellent communication skills, written and verbal
  • Strong commitment and accountability for completion of projects in accordance with team plans
  • Excellent organizational skills and attention to detail

Strongly preferred:

  • Significant experience with early drug development within a small biotech environment
  • Significant experience working within a cross-functional therapeutic program team
  • Familiarity with hybridoma or display technologies (phage-display, yeast display, etc.)

 

AC