Research Associate, Histology/Biology

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Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy, expressed RNA interference and neuroscience. Our management team has deep expertise and a track record of building exceptional life science companies.

Voyager Therapeutics seeks an entry level and highly motivated biologist to contribute to its research team at its facility in Cambridge, Massachusetts. This is a hands-on position for a person committed to helping the group conduct innovative drug discovery research while meeting deadlines and company goals. We are seeking a person who is enthusiastic about biomedical research and can work collaboratively with other scientists and team members. This is an ideal position for an individual with limited to basic experience in histological techniques and willing to expand their proficiency in methods such as tissue processing, sectioning, special staining, and immunohistochemistry methods. The successful candidate should thrive in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. Knowledge of automated image analysis, multiplexed immunohistochemistry, in-situ-hybridization, and laser capture microdissection would be a strong plus but is not required.

Responsibilities:

  • Develop, validate and execute single or multiplex IHC/ISH assays with fresh frozen or fixed CNS and peripheral tissues with chromogenic and immuno-fluorescence methods to characterize the expression of transgenes and distribution of adeno-associated gene therapy viruses in tissues from different species.
  • Coordinate the workflow in histology to meet project and company goals
  • Prepare animal specimens for histology analysis including fixation, processing, embedding, microtomy and routine/special/IHC staining.
  • Perform routine histology instrument operations with working knowledge of maintenance and troubleshooting
  • Conduct Laser Capture Microdissection to capture enriched cell populations and perform q-PCR on the micro dissected material.
  • Perform routine/special stains for CNS tissues to evaluate neuronal cell death and degeneration in CNS tissues
  • Execute and troubleshoot standard protocols, adapt new protocols into practice

Qualifications:

  • A minimum of a Bachelor’s degree in Life Sciences or related field is required
  • A Master’s degree in Life Sciences or related field is preferred
  • A minimum of 0-2 years of hands-on experience with excellent tissue handling, histology and immunohistochemistry techniques
  • Self-motivated, able to work collaboratively, highly organized with strong attention to detail
  • Good communication and presentation skills

Preferred:

  • Laser capture microdissection experience strong plus
  • Basic knowledge of neuroanatomy and neuroscience
  • Basic necropsy skills a plus
  • Existing experience in pharmaceutical/ biotechnology industry
  • Experience in cross-functional therapeutic program team
  • Experience within a start-up or small biotech environment

 

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