Research Associate Scientist, Research Vector Production

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Voyager is seeking a highly motivated research associate scientist with significant experience and demonstrated success with rAAV vector production to join our research team.

This research associate scientist will contribute hands-on to manufacturing and QC of diverse, in-house research-grade rAAV vectors for in vitro and in vivo research studies.  In this role, the individual will participate in upstream and downstream processing of small- to medium-scale research-grade batches of rAAV vectors using multiple production systems, as well as QC of these batches. Since multiple novel AAV capsids will be evaluated, development of new production methods will be a key component of the work. This individual will play an important role assisting the head of the group in prioritizing and planning the vector production work and implementing the plan. This is an ideal position for an individual who is energetic and thrives in a team-oriented, fast-paced, and cross-disciplinary small biotech company environment. This role is located in Cambridge, MA.

Responsibilities

  • Produce rAAV vectors using triple transfection and baculovirus/sf9 systems including generation of baculovirus expression vectors (BEVs) and baculovirus infected insect cells (BIICs), and vector QC
  • Develop and optimize protocols for production of rAAV vectors using triple transfection and baculovirus/sf9 systems, especially for novel vectors
  • Identify and apply effective resolutions to any technical challenges during upstream and downstream processes and QC
  • Optimize multiple cell culture platforms for rAAV vector production including mammalian and insect cells
  • Ensure adequate use of electronic tracking system for documenting and tracking vector production requests, status and inventory

Requirements

  • B.S in a biological science or chemical engineering (vectorology or bioprocessing focus) with minimum of 2-3 years of subsequent research, vector manufacturing, or process development experience
  • A minimum of 2 years of relevant experience in the production of biologics with a focus on rAAV viral vectors, including familiarity with different rAAV production systems, especially triple transfection and baculovirus/sf9 systems
  • Excellent organizational skills and attention to detail
  • Strong commitment to accountability for completion of objectives in accordance with established plans
  • Ability to be highly productive and flexible in a fluid and fast-paced work environment
  • Ability to troubleshoot manufacturing issues and find timely solutions
  • Strong written and oral communication skills

Strongly Preferred

  • A minimum of 2 years of experience within a start-up or small biotech environment
  • Experience in downstream processing technologies
  • Experience and knowledge of biologics and/or gene therapy vector manufacturing

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