Scientist/Senior Scientist, Antibody Discovery

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Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Huntington’s disease, Friedreich’s ataxia, Alzheimer’s Disease and neuropathic pain.

The Antibody Platform group at Voyager Therapeutics is looking for a highly motivated individual experienced in antibody discovery and engineering, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment.  The individual will be responsible for activities that include the design of antibody discovery and optimization campaigns, developing biochemical and cell-based screening assays for antibody therapeutic lead selection, screening of antibodies from hybridoma and display campaigns, antibody V gene sequencing, and recombinant antibody expression, purification, and characterization.  This position is located in Cambridge, MA. 

Experience/Qualifications:

  • PhD in molecular biology, biochemistry, protein/antibody engineering, immunology, or related field with 0-3 years postdoctoral biologics experience preferred, or BS/MS with 7+ years of relevant experience
  • Ability to collaborate with Biology and Vector Engineering colleagues to generate appropriate in vitro, cellular, and in vivo data packages supporting PoC
  • Substantial hands-on experience with protein binding assays (ForteBio Octet, Biacore, ELISA, flow cytometry) and developability assessment (CIC, AC-SINS, BV ELISA)
  • Hands-on experience with transient and stable expression of proteins in HEK293 and CHO cells
  • Significant hands-on experience in antibody and/or protein production (small scale) and purification (affinity, ion exchange, SEC) methodology
  • Extensive experience with antibody sequence isolation, repertoire analysis, and V region classification
  • Outstanding problem-solving skills and ability to multi-task
  • Excellent communication skills, written and verbal
  • Ability to independently analyze and present data to scientific teams
  • Strong commitment and accountability for completion of projects in accordance with team plans
  • Excellent organizational skills and attention to detail

Strongly preferred:

  • Significant experience with early drug development within a small biotech environment
  • Proven record in antibody engineering, humanization and affinity maturation
  • Significant experience working within a cross-functional therapeutic program team
  • Strong publication record in peer-reviewed journals

 

AC