Archives

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems.

Ken Y Chan, Min J Jang, Bryan B Yoo, Alon Greenbaum, Namita Ravi, Wei-Li Wu, Luis Sánchez-Guardado, Carlos Lois, Sarkis K Mazmanian, Benjamin E Deverman, Viviana Gradinaru. Nat Neurosci. 2017,

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain.

Deverman BE, Pravdo PL, Simpson BP, Kumar SR, Chan KY, Banerjee A, Wu WL, Yang B, Huber N, Pasca SP, Gradinaru V. Nat Biotechnol. 2016 Feb;34(2):204-9.

In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy.

Choudhury SR, Fitzpatrick Z, Harris AF, Maitland SA, Ferreira JS, Zhang Y, Ma S, Sharma RB, Gray-Edwards HL, Johnson JA, Johnson AK, Alonso LC, Punzo C, Wagner KR, Maguire CA,

Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10.

Yang B, Li S, Wang H, Guo Y, Gessler DJ, Cao C, Su Q, Kramer J, Zhong L, Ahmed SS, Zhang H, He R, Desrosiers RC, Brown R, Xu Z,

Recombinant AAV as a platform for translating the therapeutic potential of RNA interference.

Borel F, Kay MA, Mueller C. Mol Ther. 2014 Apr;22(4):692-701.

Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing.

Adachi K, Enoki T, Kawano Y, Veraz M, Nakai H. Nat Commun. 2014;5:3075.

Gene transfer to the CNS using recombinant adeno-associated virus.

Stoica L, Ahmed SS, Gao G, Sena-Esteves M. Curr Protoc Microbiol. 2013;Chapter 14:Unit14D.5.

Exploiting natural diversity of AAV for the design of vectors with novel properties.

Gao G, Zhong L, Danos O. Methods Mol Biol. 2011;807:93-118.

Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system.

Zhang H, Yang B, Mu X, Ahmed SS, Su Q, He R, Wang H, Mueller C, Sena-Esteves M, Brown R, Xu Z, Gao G. Mol Ther. 2011 Aug;19(8):1440-8.

A New Recombinant Adeno-Associated Virus (AAV)-Based Random Peptide Display Library System: Infection-Defective Aav1.9-3 as a Novel Detargeted Platform for Vector Evolution

Adachi K, Nakai H. Gene Ther Regul. 2010 Oct;5(1):31-55.


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