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Voyager is looking for exceptional individuals who share our passion for developing life-changing gene therapies for severe neurological diseases.

Current Openings

Senior Manager, Marketing & Commercial Development

This is an exciting multi-faceted, newly created, commercial role, in a fast-paced, innovative and dynamic environment.  The core focus of the role is to support advancement of market and commercial development in advance of the launch of Voyager’s lead program, VY-AADC, gene therapy for Parkinson’s Disease, and as such requires a broadly capable “utility player” to both help shape and develop commercial strategy in a nascent team setting while personally owning implementation of the strategy through tenacious day-to-day tactical execution.  This role will partner and work collaboratively with internal and external, cross-functional team members to ensure alignment on project goals, milestones and deliverables. The ideal candidate will possess a broad view of the healthcare system, the ability to think creatively when introducing new therapies and a proven track record of getting things done.

This position offers an extraordinary opportunity in a therapeutic area with high unmet needs, translating market insights into actionable activities to make treatment available to all appropriate patients.

Key Responsibilities

  •  Develop market and customer insights to shape critical success factors and initiatives, ensuring clarity on scenarios that are likely to impact successful commercialization
  • Co-lead the development and execution of brand and communication initiatives in support of both drug and delivery
  • Support strategic brand architecture and expression development and manage implementation
  • Co-lead development of market development plans and execute in support of global go-to-market strategy
  • Partner across functions to develop and maximize the value of Voyager commercial assessments
  • Coordinate global pricing strategy work
  • Co-lead communications efforts related to data readouts, product milestones, and key congresses

Minimum Requirements

  •  MBA/graduate degree
  • 8+ years of relevant marketing & commercial experience spanning at least two of: pharma/biotech, medical devices, hospital/IDN or payor/provider experience
  • 5+ years broad relevant professional experience
  • Pharmaceutical, biotech, or relevant consultant firm experience
  • Willingness & proven ability to personally produce high quality work as a hands-on individual contributor in a fast-paced small company setting
  • Proven ability to successfully manage multiple external agency and consultancy partners simultaneously
  • Strong analytical skills; ability to synthesize and evaluate information, draw conclusions and make recommendations
  • Exceptional communication and collaboration skills

 

Preferred Qualifications

  •  Smaller start- up company or entrepreneurial experience
  • Robust people management experience with a proven track record of talent acquisition and development

 

To apply, email careers@voyagertherapeutics.com

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Director, Business Development

Voyager is seeking a dynamic and talented Director of Business Development.  This role will play a key part in identifying and evaluating new business opportunities, including partnerships, collaboration, and licensing relating to Voyager’s platform and programs and acquisition of new assets and technologies, as well as structuring and negotiating terms for related transactions.  This leader will build and maintain strong relationships within the team, cross-functionally, and externally.  This newly created role will report to the Vice President of Corporate and Business Development.

Responsibilities

  • Forge strong relationships and work closely with internal stakeholders (including R&D, clinical development, technology operations, program management, finance, and others) to understand and support objectives and their translation into business development opportunities.
  • Identify, evaluate, propose, and present new business opportunities, including partnerships, collaborations, licensing, or acquisitions.
  • Participate in or drive the structuring, negotiation, and execution of deals and transactions in furtherance of business development and corporate objectives.
  • Build strong relationships and networks with potential external partners.
  • Stay closely abreast of research developments in the field via published literature, trade press, conferences, patent filings, and relationships across academia and industry.
  • Work collaboratively with colleagues in finance group to create valuation models relevant to programs and opportunities being explored.
  • Contribute to development and evolution of corporate and business development strategies and objectives.
  • Foster and contribute to a vibrant team and company culture.

Minimum Requirements

  • Graduate degree in relevant scientific or medical discipline (e.g., PhD, MD) and/or research experience in gene therapy, genetically-driven medicine, or CNS disorders preferred and MBA or JD desirable; bachelor’s degree required (with major in the biological or chemical sciences preferred).
  • At least 8 years of experience in the biotechnology or pharmaceuticals industry overall with a minimum of 5 years of experience in business development.  Exposure to gene therapy, genetically-driven medicine, or CNS disorders preferred.
  • Substantial deal and negotiation experience with track record of participation and leadership in executed transactions (e.g., partnership, collaboration, licensing, research agreements).
  • High motivation and passion for mission.
  • Facility and comfort with working both independently and collaboratively as required.
  • Exceptional communication and interpersonal skills.
  • Strong business acumen and financial literacy.
  • Creativity, innovative thinking, and open-mindedness.
  • Analytical approach, strong critical thinking and decision-making skills.
  • Ability to “drive” complex processes and transactions internally and externally, experience leading cross-functional projects.
  • Excellent leadership qualities, including strategic thinking capability, attention to mentoring and development of other team members, and thoughtfulness about team building.
  • Understanding of drug development and regulatory process as it pertains to business development activities.
  • Knowledge of competitive landscape and industry players preferred, capability to ascend the learning curve efficiently required.
  • Thrives in dynamic, intellectually stimulating environment.

 

 

 

To apply, email careers@voyagertherapeutics.com

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Industrial Co-Op Opportunity on Insect cell/baculovirus production of AAV (Approx. 12 months Contract‐ Available October 2018, )

Project Title:
‐ Kinetics of adeno associated virus (AAV) production with the insect cell baculovirus expression
system

Scope:
‐ This project will develop processes and methods to monitor, characterize and understand the kinetics
of AAV production using an insect cell baculovirus system.
‐ The goal of this project is to first characterize the system dynamics and then develop rational
strategies for optimization of AAV production
‐ The individual will use established and will develop novel methodologies to enable qualitative and
quantitative measurements of cell parameters, critical metabolites, baculoviruses, and AAV products
in small scale systems, e.g. shake flasks, as well as fully instrumented bioreactors.
‐ Additionally, this project aims to find insights between different process conditions (e.g. pH, DO,
pCO2, nutrients, production scale, shear, etc…), their interplay and overall AAV production dynamics
Duration:

Candidate Qualifications:

– Currently enrolled in a PhD granting program in Chemical/Biochemical Engineering or similar areas.
‐ PhD thesis with emphasis on insect cell baculovirus bioprocessing (required).
‐ At least 2 years of hands-on experience with insect cell culture and baculovirus expression (required)
‐ Experience in AAV production with BEVS (preference, but not required)
‐ Undergraduate in Chemical/Biochemical Engineering or similar areas
‐ In-depth expertise of insect cell metabolism and baculovirus biology
‐ Hands-on experience with operating fully instrumented bioreactors and knowledgeable of bioreactor
scale-up principles
‐ Experience in multiple analytical techniques, such as ELISA, PCR, HPLC, Flow cytometry, etc..
‐ Good communication skills. Oral and writing.

To apply, email careers@voyagertherapeutics.com

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Position Summary

The Director, Human Resources will play an important role in the Voyager organization.   This new role will focus on organizational development, employee development and culture within our fast growing organization.   This new leader will build and maintain strong relationships with Voyager leadership, and and will provide advice and support on talent management, employee relations, communications and longer-term organizational planning.   The Director will focus on developing and implementing programs which build core skills, accelerate learning, provide real-time feedback and improve cross-functional information sharing and engagement.   This position will lead all business partner work, and will develop a team who can effectively build and scale our organization, while maintaining the critical elements of our culture and identity.

Responsibilities

  • Build relationships with organizational leaders to understand evolving needs for critical HR programs that helps align needs and program priorities.
  • Develop strong, real-time talent management system which links our people to critical company goals, and provides frequent feedback on performance and opportunities to grow and learn
  • Act as coach and advisor to managers at all levels on effectively managing people.   Help design key training and development solutions that strengthen manager capabilities
  • Enhance company communication vehicles across the organization in a way that promotes culture, key learning, effective information sharing and skill building.   Develop effective means to communicate basic program requirements such as policies, tools & templates, etc.
  • Manage rollout of annual engagement survey and follow up with communication of results and design and implementation of key action plans to maintain positive results, improve in opportunity areas
  • Review and improve company communications on job requirements, career paths, recruiting postings to establish compelling descriptions of our work with clear expectations on performance success
  • Promote strong culture through review and design of key organizational processes, from onboarding through all areas of employee experience.   With team, improve and redesign processes to enhance effectiveness while keeping process simple and scalable
  • Develop short and long-term goals at each functional level, and design solutions which fit both broad organizational needs and functional-specific solutions
  • Work with HR Operations Manager to design and share key metrics on organizational performance and employees, including talent management, talent acquisition, compensation competitiveness, retention, and other areas

Experience and Skills Desired

  • Bachelor’s Degree required, advanced study in relevant field desirable
  • Minimum of 10 years of progressive HR experience in business partner roles, with broad generalist knowledge in employee relations, compensation, organizational development, training and talent acquisition.
  • Biotech or pharma industry experience required
  • Strong relationship building and coaching skills at all levels of the organization
  • Excellent project management and organizational skills
  • Solid business acumen, with ability to analyze data, manage budgets and measure results and effectiveness of programs
  • flexible, resourceful, and with a great sense of humor, ability to work effectively on multiple tasks on deadline and under pressure with grace and success
  • Strong communication skills, both as an effective writer and presenter of information
  • Strong interpersonal and problem-solving skills are required
To apply, email careers@voyagertherapeutics.com

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Director of Talent Acquisition

Voyager seeks its first Director of Talent Acquisition to lead our ongoing efforts to attract and retain outstanding talent in our fast-growing organization.  

The Director will manage current talent acquisition efforts while building processes, brand, team and strategy to insure longer-term success and alignment with key organizational goals.   This role will oversee the full recruiting cycle from planning through successful onboarding, and will help develop the Voyager recruiting process to continue to deliver strong candidates with an effective process and positive candidate experience.

Responsibilities

  • Lead the talent acquisition team, and manage staffing to support workforce needs.
  • Partner with business leaders to enhance current recruitment efforts and pipeline development. develop longer-range plans for recruiting readiness aligned with company’s plans
  • Develop effective recruitment strategy for each area of the organization, identifying current and future candidates from a variety of sourcing methods
  • Build competitive knowledge of gene therapy, neuroscience, both in industry and academic worlds,  and other key areas to accelerate sourcing of highly qualified talent for current and future needs.
  • Define Voyager recruitment process, establishing and training in best practices for sourcing, screening, interviewing, referencing and feedback, negotiation of offers, onboarding and all candidate interactions and communications
  • Enhance Voyager’s efforts on branding and messaging and develop plan for effective recruiting messaging with audiences including candidates and partners
  • Evolve company’s recruiting techniques to assess candidates on both skills and culture fit to maximize fast integration and likely retention.  Promotes company core values and importance of diversity and inclusion
  • Lead implementation of new applicant tracking system, train managers on Voyager process and use of new system and tools
  • Review and report on recruiting effectiveness using metrics which assess progress and success
  • Build relationships with key external partners for specialized staffing needs or for additional resourcing needed to attract and engage target candidates

Experience and requirements

  • Bachelor’s degree required, with 10+ years of recruiting experience, including some managing recruiters
  • Biotech work experience required, with demonstrated track record in recruitment
  • Highly organized, effectively multi-tasker who can build processes and organization
  • Excellent communicator and relationship builder who can develop talent, give effective feedback
  • Strong professional presentation who is a highly effective representative for Voyager
To apply, email careers@voyagertherapeutics.com

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Senior Director, Information Technology

Voyager is seeking a customer-centric, Information Technology professional to lead the evolution of Voyager’s technology landscape as the company progresses to becoming a commercial entity.  This leader will work closely with business partners, senior management, strategic partners, and other stakeholders to align systems infrastructure, applications, and ongoing investments to optimally support Voyager in achieving our strategic goals.  Additionally, the Senior Director, Information Technology, will lead Voyager’s cybersecurity efforts and serve as the company’s Information Security Officer.

Responsibilities

  •  Provide cross functional leadership on technology and data initiatives. Evolve and implement the technology blueprint and strategic plan in support of Voyager’s strategic goals.
  • Instill project management discipline on key programs involving platform selection and implementation.
  • Define and implement a company- wide cybersecurity program that safeguards Voyager IP while not diminishing organizational agility. Identify threats and vulnerabilities, implement preventive measures, and identify, report, and control incidents.
  • Lead company-wide efforts around data curation, governance, accessibility, and analytics.
  • Lead the development and maturation of a world class IT organization. Attract, develop, engage and retain key talent.
  • Maintain ongoing knowledge of industry and technology trends. Assess existing and new technologies in conjunction with the needs of the organization in order to evaluate, plan, and execute the necessary changes to the technology landscape.
  • Support regulatory compliance including SOX, CFR Part 11, GDPR, and others as required.
  • Develop and communicate the IT service portfolio in support of day to day operations. Ensure that IT services are monitored and measured to meet the highest levels of quality and performance. 
  • Develop and manage the IT budget within organizational spending parameters.

Skills

  • Ability to think beyond the current business and capability needed. Comfort with “stepping outside the box” of traditional IT roles.
  • Ability to maintain a deep understanding of key technology changes in industry as it applies to the cloud and biopharmaceuticals.
  • Demonstrated ability to influence and collaborate with scientific/business/functional leaders.
  • Ability to lead the development and execution of a progressive, realistic, IT strategy in support of the company’s strategic growth plan.
  • Strong project management skills; experience in organizing, planning and executing cross functional projects from vision through implementation, involving internal personnel, contractors, and vendors. Ability to analyze project needs and determine resources needed to meet objectives.
  • Ability to manage all aspects of vendor relationships, including managed service providers.
  • Strong oral and written communication skills.
  • Demonstrated analytical, problem-solving, and conceptual skills.

Qualifications and Experience

 

  • Degree in Information Technology, Computer Science, or related field, plus 10+ years of relevant experience working in IT within Biotech/Bio Pharma/Medical Device industries. Preference to working in an environment with validated solutions.
  • Seven (7)+ years of experience implementing cloud based platforms and technologies across functional lines.
  • Experience supporting or managing an Information Security or Cyber Security program.
  • Experience managing and supporting cloud based systems such as Oracle ERP and Veeva.
  • Experience with business process design/redesign.
  • Experience with evaluating, implementing and managing scientific data management platforms.
  • Ability to adapt to increasing scope and complexity of work brought on by growth/change. Aptitude to help others manage through change.
  • Executive presence and the ability to credibly engage with management and the board of directors.

 

To apply, email careers@voyagertherapeutics.com

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Scientist l, Neuroscience ( in-vivo )

Voyager is seeking a highly motivated neurobiologist to contribute to our research team. This is an ideal position for an individual with a strong background in in vivo experimental methods and readouts, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental execution and data analysis for research studies supporting cutting edge therapeutic programs and platform discovery research in neurodegenerative disease areas. The successful candidate will have extensive prior experience in drug discovery in neurodegenerative diseases and with hands-on techniques in stereotaxic surgery, in vivo behavioral assays of rodent models, CNS tissue dissection, and downstream analysis (RT-qPCR, western blot and ELISA). This position is located in Cambridge, MA and reports to a Principal Scientist, Neuroscience.

 Responsibilities

  • Drive the planning strategies to include designing and executing rodent in vivo experiments: animal handling, test article dosing via various administration routes including stereotaxic surgeries
  • Performing behavioral assays of rodent models for various neurodegenerative diseases to assess motor and cognitive dysfunction
  • Performing perfusion, tissue dissection and collection
  • Conducting ex vivo tissue analysis (ELISA, western blot, RT-qPCR, etc.)
  • Performing data analyses and delivering data presentation to the research team
  • Ensuring maintenance of industry-quality records to provide documentation

 

Minimum Requirements

  • PhD (1-3 years) or MS (+ 8 years) experience in neuroscience or related discipline
  • Outstanding problem-solving skills
  • Ability to be highly productive in a fluid and fast-paced work environment
  • Hands-on experience with rodent handling, stereotaxic surgeries, drug administration, tissue dissection and analysis
  • Hands-on experience in behavioral assays of various rodent models for neurodegenerative diseases
  • Molecular and cell biology experience
  • Excellent communication skills, written and verbal
  • Ability to independently analyze and present data to the scientific teams
  • Strong commitment to accountability for completion of projects in accordance with team plans
  • Excellent organizational skill and attention to detail

 Strongly Preferred

  • Experience with drug discovery for neurodegenerative diseases
  • Experience on cross-functional therapeutic program team
  • Experience within a start-up or small biotech environment

 

 

18 pz    

To apply, email careers@voyagertherapeutics.com

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Senior Field Clinical Engineer ( Travel Domestic/Int’l )

Voyager Therapeutics is seeking an experienced, highly motivated Senior Field Clinical Engineer to provide field procedural support of neurosurgical clinical research including clinical trials and new technology assessments. This role is newly created and will collaborate with our clinical development staff to provide education to investigators, research staff and institutional personnel at clinical trial/project sites. The individual will serve as a technical conduit between neurosurgeons and Voyager.   S/he will maintain expert knowledge and consult on technical and clinical advancements. S/he will identify and routinely use the most effective, cost efficient and best practices and will continually evaluate the effectiveness and appropriateness of relevant field activities. 

Responsibilities

  • Help with identification and evaluation of quality neurosurgical centers, appropriate Voyager Clinical Studies.
  • Develop and assist with training of facility staff on the requirements of the study as directed and share best practices, while encouraging the site teams to adhere to GCP, regulations and norms, protocol and surgical / procedural manuals
  • Attend procedures to support the study as required and provide feedback to clinical and Voyager organization on the evaluation of quality and deployment of technology and surgical procedures
  •  Continually work with clinical teams in support of study needs to meet corporate objectives. May assist in activities to help meet enrollment objectives, promote protocol and regulatory compliance, produce training documentation, and provide continuous technical support.
  • Manage day-to day operations of the imaging core vendor to ensure efficient work process and deliverables are met according to study and corporate timelines.
  • Work effectively on internal cross-function program teams in support of new technology including new surgical devices and provide support across functional areas to help develop new product and procedural iterations and technical support.
  • Provide product feedback, comments and suggestions and work with clinical development and neurosurgeons to create and deploy educational modules and materials.
  • Collaborate with the clinical research department as needed on clinical trial design, clinical data collection requirements, investigator training needs, and trial execution.
  • Coordinates clinical evaluation of products.  Collects and studies information about new and existing products and provides updates to clinical team.
  • Maintains expert status and continuing clinical and technical proficiency in product expertise that goes beyond features and benefits, focusing also on design, development, clinical application.
  • nterprets results in preparation for product applications by evaluating clinical and scientific and risk data and literature, stays abreast of current clinical practice.
  • Participates in and supports audits as required.
  • Participate in root cause analysis, preventive or corrective actions, effectiveness monitoring, and other quality metrics.
  • Builds and maintains relationships with neurosurgical KOLs.

Minimum Requirements

  •  Degree in Biomedical or related Engineering, Biological Sciences, Nursing, or a related field.
  • 3+ years of relevant clinical experience in CNS Navigation Deep Brain Stimulation (DBS).
  • Working knowledge of MRI imaging modalities and navigation systems
  • Current knowledge of quality DBS centers in U.S. and beyond, ability to research and evaluate new centers.
  • Excellent communication skills, including demonstrated written and verbal communication, interpersonal, facilitation, solid teaching and presentation skills
  •  Strong organizational skills including project management, personal organization organizational, time management and follow-up skills, with the ability to meet deadlines as well as the ability to help others work to shared deliverables and deadlines.
  • Strong analytical skills, including good quantitative skills and ability to work effectively with data to review input and analyze effectively. Strong, hands-on computer skills with Microsoft modules and other applications
  •  Evaluation, originality and/or ingenuity required.
  • Ability to travel (domestic and internationally) up to 50% and to travel flexibly, with travel schedule fluctuating based on patient enrollment and program needs.
  • Excellent reputation for building relationships across various levels of an organization, including with clinical/medical/surgical KOLs.
  • Positive and professional attitude, passionate about work, science and technology, in the service of clinical study subjects and site teams, as well as patients and their health care practitioners associated with relevant medical interventions
  • Effectively represents Voyager as a technical clinical expert in the field.
To apply, email careers@voyagertherapeutics.com

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Program Manager

This is an exciting multi-faceted program management role, reporting to the Vice President, Program Management, in a fast-paced, innovative and dynamic environment.  The core focus of the role is to support advancement of multiple exciting preclinical and clinical stage pipeline programs, with ownership of cross-functional coordination and development, and tracking program progress, timelines, and budgets.  This role will be a key point of team communications for effective meeting organization, documentation, and action follow-up. This role will partner and work collaboratively with cross-functional team members to ensure alignment on project goals, milestones and deliverables.

Roles and Responsibilities

  • Partner with Program Team Leaders to integrate, document and communicate program plans
  • Manage and track program timelines, deliverables, metrics and budget
  • Interface with Finance to coordinate program related budget and resource planning and re-forecasting
  • Ensure alignment and information flow among team members and all stakeholders; drive coordination of cross-functional activities; and facilitate the execution of agreed upon program plans within a team environment
  • Assist in risk/opportunity identification; issue resolution and escalation, as well as contingency and scenario planning
  • Organize team meetings, including preparing agenda and drafting meeting minutes, facilitating discussions, following up action items, as well as overall program correspondence
  • Manage action item log, risk/issue log, and decision log on behalf of the program team
  • Assist Program Leaders in preparing timely program updates for program team meetings, leadership team reviews, and board meetings, as appropriate, to help drive effective decision making and the advancement of the program
  • Ensure effective Alliance Management as needed: manage relationships with partner team and coordinate joint activities/deliverables with partners
  • Assist in driving continuous improvement within the Voyager Team to streamline processes and improve communication and flow of information

Requirements

  • Bachelor’s degree in sciences. Advanced degree preferred
  • Minimum 5-8 years in scientific leadership or program management within the biotechnology or pharmaceutical industry
  • Knowledge and experience operating in drug discovery and development
  • Strong interpersonal skills with demonstrated ability to work well in a collaborative and dynamic team environment
  • Strong analytical and problem-solving skills; ability to combine attention to detail with big picture perspective
  • Excellent written and oral communication, including presentation, negotiation, team building, and facilitation skills
  • Excellent organizational skills, able to work independently and proactively, prioritize and manage multiple tasks simultaneously
  • Proven effectiveness in a quick-changing, fast-paced environment, a strong team player with high energy and a can-do attitude
  • Alliance Management experience, a plus
To apply, email careers@voyagertherapeutics.com

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Medical Writer

Voyager is seeking a Medical Writer to support a cross-functional team including Medical, clinical, CMC, and regulatory; the position will report to Medical Affairs. We are looking for a full-time contract writer for a minimum of 6 months with the potential to convert to a permanent position.

This individual will provide writing, editing, and project management support to the development of clinical documents, CMC, clinical, and medical publications and congress presentations, and regulatory filings as needed.

The ideal candidate will have a minimum of 3 years of writing experience for CMC, clinical, and/or regulatory clients and a desire to move into a more Medical Affairs-focused role.

Minimum requirements

  • Bachelor’s degree in a relevant scientific discipline; advanced degree strongly preferred
  • Three years of writing experience either in-house or as a contractor to biotech or biotech support (e.g. CRO, medical writing agency) organizations
  • Excellent writing and editing skills
  • Strong on-line database/literature search skills
  • Strong project management skills with proven ability to drive projects to completion on an agreed timeline
  • Intermediate MSWord and PowerPoint user
  • Ability to work effectively across disciplines and writing styles

Preferred qualifications

  • Understanding of statistics
  • Experience with early-stage clinical, CMC, and regulatory development
  • Experience working in or for a matrixed organization
  • Working knowledge of EndNote
  • Experience working with or managing support agencies

Must be local to Cambridge, MA. May work remotely if available on an as-needed basis to be in-house on short notice.

To apply, email careers@voyagertherapeutics.com

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Senior Scientist/Principal Scientist, Vector Engineering

Voyager Therapeutics seeks a highly motivated and experienced molecular biologist to contribute to its research team at its facility in Cambridge, Massachusetts.

The senior/principal scientist will play a leading role in our AAV capsid discovery effort. In this role, the individual will actively take part in strategizing on and designing novel approaches to screening and identifying AAV capsids specifically targeting CNS or other tissues and planning and implementing these approaches. The candidate will interact closely with the research team to evaluate and characterize AAV capsids discovered internally or licensed from external sources. The individual will also participate in various therapeutic programs in the company as well as manage studies conducted at collaborators’ labs and contract research organizations. Extensive prior hands-on expertise in molecular and cellular techniques, and significant experience with AAV capsid identification/optimization are required. This is an ideal position for an individual with a strong background in AAV biology and gene therapy, who has a can-do attitude and strong work ethic, and thrives in a team-oriented, fast-paced, and cross-disciplinary small biotech environment.

Responsibilities

  • Drive a leading role in building and optimizing novel AAV capsid discovery platform based on deep understanding of AAV Biology
  • Screening for capsids that have improved tropism for tissues of interest using various approaches in different animal models including NHP
  • Characterize and evaluate capsids with potential to be used in our gene therapy programs using a variety of molecular/biochemical approaches
  • Participate in AAV transgene construction and optimization for pipeline projects and future programs, carrying out molecular biology studies in collaboration with the scientific teams in the company
  • Develop and optimize new technologies to advance AAV-based gene therapy

Requirements

  • Ph.D in Molecular/Cellular Biology or related discipline
  • 5-10 years of hands-on experience in gene therapy and drug discovery research
  • Extensive hands-on experience with molecular and cellular techniques
  • Proven track record in AAV capsid discovery/optimization/characterization including AAV variant library design, construction, production, and screening
  • Outstanding problem-solving skills
  • Significant experience with managing and maintaining collaborations with other laboratories and/or CROs
  • Ability to be highly productive in a fluid, fast-paced and team-oriented work environment

Strongly Preferred

  • Significant experience in a small biotech environment
  • Significant experience on cross-functional therapeutic program team
  • Working knowledge of neurobiology and at least several neurodegenerative diseases
  • Strong publication record in peer-reviewed journals

 

 

 

To apply, email careers@voyagertherapeutics.com

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Senior Toxicologist

Voyager is seeking a Senior Toxicologist to help advance our drug development candidates for investigating life-saving gene therapies for severe neurological disease.

This newly created role requires a firm understanding of biologics/vaccine (large biomolecules) safety assessment in multiple species such as rodents, lagomorphs, ungulates, canines and non- human primates.

As the Senior Toxicologist, you will lead all aspects of toxicology work for select nonclinical programs to enable gene therapy candidates from research through development and IND enabling studies. You will design, execute, and interpret nonclinical safety studies conducted in multiple species. You will also be heavily involved in regulatory submissions and interactions with various health authorities as well as the in house Clinical Team.

The successful candidate must have the ability to multitask, to function effectively in a fast-paced environment. Be capable of conducting work independently, but also capable of pulling in subject matter experts when necessary to lead the conversation. 

The individual must have an overall knowledge of biology to integrate all animal findings and understand the relevance of the findings to the human situation and communicate succinctly when issues arise.

Responsibilities

  • In conjunction with program teams, develop toxicology strategies and provide expert support to research and development projects.
  • Collaborate on the design of non-GLP investigative and pharmacology studies to support developmental compounds, as needed.
  • Directly interface with contract research organizations (CROs) to request quotes and derive cost estimates and work closely with Finance to develop program budgets. Additional responsibilities include working closely with the contracts group to develop confidentiality agreements, statements of work and track all expenses and invoices.
  • Plan, coordinate, execute, and oversee the conduct of external GLP toxicology studies to support development programs.
  • Review, summarize and integrate complex data sets across multiple disciplines
  • Manage the preparation and presentation of nonclinical safety data for project teams, portfolio management presentations, and internal /external partners and scientific groups.
  • Provide strategic advice to project teams and senior management including evaluation of conclusions and potential impact of results on program and clinical/regulatory strategy.
  • Finalize toxicology reports and all sub-vendor reports, manage the tabular presentation of data in accordance with CTD format and have a familiarity with SEND requirements.
  • Support the preparation of national and international regulatory submissions and interactions with governments. And be capable of effective communications with regulatory bodies in the process of product defense.
  • Manage and prepare toxicological risk assessments to support drug development and manufacturing.
  • Interact cross functionally with Research, Regulatory, Clinical and Manufacturing.
  • Work closely with Clinical to support and defend with data the clinical trial design plans.
  • Knowledge of archiving requirements a must.

Qualifications

  • Doctoral degree and training in a field related to industrial pharmacology /Toxicology in a scientific discipline that encompasses the basic biologic sciences, including virology, molecular biology, histology and pathology and DMPK
  • Minimum of 10 years of pharmaceutical or biotechnology industry experience as a nonclinical toxicologist.
  • Proficient in both verbal and written communications.
  • Required ability to plan travel and oversee conduct of and necropsy of animals in a study.
  • Knowledge of global regulatory guidances (ICH /FDA) and Good Laboratory Practices.
  • Must be able to critically evaluate written and published toxicology documents for overall quality and acceptability of scientific interpretations.
  • Experience in developing toxicology program to support early and later stage drug development and in preparing regulatory filings such as INDs/CTAs.

 

Travel Description: This role requires periods of heavy travel.

Off travel periods: Attendance will be conducted in Voyager Offices, Cambridge MA.

On- travel periods may include:

Travel 3 times a week for 8 weeks, plus visits to the sub-vendors

Domestic Travel includes:             40% California, Michigan

International Travel includes        10% Canada

 

To apply, email careers@voyagertherapeutics.com

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Senior Scientist/Engineer, Process Development (Pilot Plant Focus)

Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes is central for establishing successful gene therapy applications.  Voyager is seeking a highly motivated Senior Scientist/Engineer to join the Process Development Group with a focus on management of our internal Pilot Plant. The qualified candidate will be a leader within the group with a strong background and expertise in upstream production, downstream purification, and/or managing a pilot plant for the manufacture of biologic therapeutics. Primary responsibilities will include the planning and carrying out of large scale productions (e.g. 250 L) of various rAAV products, management of a small group of technicians, writing and management of appropriate documentation (e.g. SOPs, batch records, campaign reports), involvement with technology transfer activities and large-scale process development activities.  The ability to independently manage and schedule activities within the pilot plant, analyze data and report the results of their and other’s work in a concise and well documented manner, and to take the initiative to successfully drive Voyager’s projects and manufacturing process are all important aspects of the position.  

Responsibilities

  • Manage the pilot plant group within Process Development, responsible for non-clinical, large-scale manufacturing activities using the Sf9/baculovirus production system for rAAV production
  • Develop and manage a small and efficient group of technicians
  • Create and maintain a production schedule and customer calendar for various product campaigns
  • Lead technology transfer within the pilot plant group, carrying out facility fit and lessons learned activities, while assisting with technology transfer to external manufacturing parties
  • Write various experimental reports, SOPs, batch records, campaign reports, technology transfer documents and participate in authoring relevant regulatory documents
  • Perform various scale-up process development activities as part of ongoing campaigns
  • Be the Voyager point person for and maintain various external relationships with partners, vendors and CMOs/CROs
  • Lead innovation, development and optimization of the Voyager platform manufacturing process at scale
  • Be highly involved with and help lead the Process Development group’s IP, conference and publication strategy

Qualifications

  • Degree in chemical engineering, biology, biochemistry, chemistry, biotechnology, or related fields
  • PhD degree in relevant subject matter (e.g. chromatography/filtration of biologics or mammalian production systems) with 5+ years industrial experience in process development and/or biologic therapeutic pilot plants; or a BS degree with 13+ years industrial experience in process development and/or biologic therapeutic pilot plants
  • Previous experience working with protein biologics or vaccines is a must, prior experience working with rAAV products desired
  • Previous experience working within and/or managing a pilot plant desired
  • Proficient with the use of Akta and other chromatography systems, UF\DF systems, and cell filtration devices; or proficient with aseptic techniques and the use of shake flasks, wave based bioreactors, and various stirred tank bioreactors at large-scale
  • Strong desire to learn multiple new techniques and willingness to work as part of and help lead a larger team
  • Significant attention to detail and accuracy in developing, reviewing and following protocols, SOPs, batch records and technology transfer documents
  • Ability to be highly productive in a fluid, fast-paced and teamwork oriented environment
  • Prior experience managing a team, co-ops or direct reports is a must
 
 
To apply, email careers@voyagertherapeutics.com

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Senior Scientist – Analytical Sciences Outsourcing

 Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases.  Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.

Voyager is seeking a highly motivated scientist to manage the Analytical Development and Testing conducted at External Contract Research Organizations (CROs). The qualified candidate will be responsible, in collaboration with Voyager’s Analytical Development and Quality, to oversee the qualification, transfer and execution of new state-of-the-art analytical methods to be used for release and characterization of Voyager’s clinical and commercial products at external CROs. Additionally, the individual will partner closely with Manufacturing to ensure constantly update status of lot release and any pending investigation or other issues requiring speedy resolution.

This position is located in Cambridge, MA, reporting to the Director, External Manufacturing & Supply. The candidate is required to travel, as needed, to CROs in US or overseas. Travel requirements will vary but may be up to 50%, as needed.

 

Primary responsibilities

  •  Develop external analytical development and testing project plans for existing and envisioned projects, with input from other Technical Operations functions (process development, analytical development, manufacturing and Quality)
  • Manage and participate in tech transfer of analytical methods to CMO’s/CRO’s
  • Develop analytical methodologies and strategies needed to progress products in the pipeline including method development, process support, formulation and stability support, product characterization and method qualifications
  • As member of CMC team meeting, provide estimates for the resources, cost, timeline tasks, and alternative options to accomplish desired schedule
  • Coordinate the interaction of the CMC cross-functional projects among Voyager personnel, and between Voyager and the CROs.
  • Work closely with CROs used to test GMP material, using site visits and frequent communication with CRO team members to update status of projects
  • Interact with program core teams to ensure alignment of CMC analytical development and testing plan with overall program strategy, and the requirements of pre-clinical and clinical teams
  • Monitor scope, milestones, dependencies, and costs associated with CRO project and the timelines for CRO deliverables.
  • Drive projects through project goals to ensure compliance to defined schedule.
  • Interact with finance to appraise them of changes in cost and assignment of work orders to specific functions and tasks
  • Create and maintain comprehensive risk management plan for product testing
  • Working with the CMC team, provide effective mitigation and escalation strategies for project risks and CMC issues.
  • Manage short and long-term analytical development and testing needs for projects and impact into supply of drug substance and drug product and communicate levels to internal project teams.
  • Develop and update standard external CMC plans, based on process and historical data, to provide guidance on cost and FTEs required to manage and produce GMP material for new Development projects
  • Manage transition of CMC project from research to development and from early stage to late stage production at a CRO.
  • Strengthen and maintain relationships with key Voyager project team employees and outside vendors and suppliers of CMC services.
  • Ensure project teams adhere to company and departmental policies, procedures, and standards for storage of data related to product production
  • Develop and deliver scientific presentations, prepare clear and concise technical reports, participate in project teams, and contribute to regulatory filings

Minimum Qualifications

  • PhD or Masters in analytical chemistry, biotech, biochemistry or a related field
  • Minimum 5+ (with a PhD) or 15+ years (with an MS) of analytical development experience in industry
  • In-practice knowledge of the ICH for assay qualification and validation
  • Demonstrated ability to efficiently develop an assay from conception to a qualified/pre-validated state
  • Experience with bioassay development for biologics/vaccines/gene therapy
  • Experience managing outsourced analytical development
  • Strong project management skills
  • Candidate should be detail-oriented, self-motivated, goal driven, and should be able to work effectively on teams to progress projects.
  • Demonstrated ability to multi-task and be highly productive in a fluid and fast-paced environment
  • Ability to write and communicate effectively with cross-functional teams

Preferred Qualifications

  • Experience in developing methods and performing the analysis of AAV or other similar viral vectors
  • Industrial experience and an understanding of the biologics drug development process is desired.
To apply, email careers@voyagertherapeutics.com

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Scientist, Research Vector Production

Voyager is seeking a highly motivated scientist with significant experience and demonstrated success with rAAV vector production to join our research team.

This Scientist will contribute hands-on to manufacturing and QC of diverse, in-house research-grade rAAV vectors for in vitro and in vivo research studies, and be responsible for ordering, maintaining and tracking critical plasmids and specialized reagents for the vector production group. In this role, the individual will participate in upstream and downstream processing of small- to medium-scale research-grade batches of rAAV vectors using multiple production systems, as well as QC of these batches. Since multiple novel AAV capsids will be evaluated, development of new production methods will be a key component of the work. This individual will play an important role assisting the head of the group in prioritizing and planning the vector production work and implementing the plan. This is an ideal position for an individual who is energetic and thrives in a team-oriented, fast-paced, and cross-disciplinary small biotech company environment. This role is located in Cambridge, MA.

Responsibilities

  • Produce rAAV vectors using triple transfection and baculovirus/sf9 systems including generation of baculovirus expression vectors (BEVs) and baculovirus infected insect cells (BIICs), and vector QC
  • Develop and optimize protocols for production of rAAV vectors using triple transfection and baculovirus/sf9 systems, especially for novel vectors
  • Identify and apply effective resolutions to any technical challenges during upstream and downstream processes and QC
  • Optimize multiple cell culture platforms for rAAV vector production including mammalian and insect cells
  • Ensure adequate use of electronic tracking system for documenting and tracking vector production requests, status and inventory
  • Order, maintain and track critical plasmids and specialized reagents for vector production group

Requirements

  • M.S. or Ph.D. in a biological science or chemical engineering (vectorology or bioprocessing focus) with minimum of 5-7 years of subsequent research, vector manufacturing, or process development experience
  • Minimum 2 years of relevant experience in the production of biologics with a focus on rAAV viral vectors, including familiarity with different rAAV production systems, especially triple transfection and baculovirus/sf9 systems
  • Excellent organizational skills and attention to detail
  • Strong commitment to accountability for completion of objectives in accordance with established plans
  • Ability to be highly productive and flexible in a fluid and fast-paced work environment
  • Ability to troubleshoot manufacturing issues and find timely solutions
  • Strong written and oral communication skills

Strongly Preferred

  • Minimum 2 years of experience within a start-up or small biotech environment
  • Experience and knowledge of biologics and/or gene therapy vector manufacturing

 #18JH

To apply, email careers@voyagertherapeutics.com

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Associate Director/Principal Research Scientist, Tau/Neuroscience

Voyager is seeking a highly motivated neuroscientist and leader with substantial experience and demonstrated success with early stage drug discovery for Alzheimer’s Disease and tau protein-related neurodegeneration to provide biology leadership for advancing our AAV gene therapy tau program. This is an ideal position for an individual who is energetic and thrives in a team-oriented, fast-paced, and cross-disciplinary small biotech company environment. This role is located in Cambridge, MA.

Responsibilities

  • Biology leadership for the tau program.
  • Development of preclinical program plans in research, communication of changes and progress, and sharing of expertise with others.
  • Management of a small team of scientists and research associates.
  • Attendance of relevant scientific conferences to network with academia and industry, and to stay current in relevant research.

 Requirements:

  • Ph.D. in Neuroscience with 8-12 years industry experience.
  • Minimum of 5 years experience in a supervisory role in industry
  • Extensive experience with tau and neurodegeneration
  • Significant experience with drug discovery and development for neurological disorders, including neurodegenerative diseases
  • In-depth familiarity with target validation and lead identification and optimization using molecular, cellular, and in vivo methodologies
  • Outstanding problem-solving skills
  • Ability to be highly productive in a fluid and fast-paced work environment
  • Strong publication record and experience in presenting research
  • Ability to independently analyze and present data to scientific team

Strongly Preferred

  • Experience with antibody drug discovery and development for neurodegenerative diseases
  • Experience on cross-functional therapeutic program team
  • Experience within a start-up or small biotech environment
To apply, email careers@voyagertherapeutics.com

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Director, External Manufacturing and Supply

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes is central for establishing successful gene therapy applications. Voyager is seeking Director, External Manufacturing and Supply who will manage multiple CMC projects with CMOs, as well as the overall Supply Chain network for clinical material distribution.

This role leads external manufacturing function at Voyager and assists the cross-functional interaction among the internal development team (process development, analytical development and Quality teams) and the CMO, particularly being responsible for the interaction with the CMO project managers.  S/he develops CMC project budgets, timelines, and risk assessments, and is responsible for performance against these parameters.  The individual actively monitors and reports on project status, the financial status of the work within the CMOs, interacts regularly with the program core team and other functions as necessary to communicate the risks and decisions required and highlights assumptions associated with CMC timelines.

The role reports into the Voyager Chief Technical Operations Officer and supervises Manufacturing Sciences engineers in charge of CMO oversight. This position is located in Cambridge, MA and will travel 20-50% ( U.S. / Int’l ).

Responsibilities

  • Develops and implements overall strategy for External Manufacturing and Supply, in collaboration with other Technical Operations functions
  • Lead the development of external CMC project plans for existing and envisioned projects, with input from other Technical Operations functions (process development, analytical development, and Quality)
  • Manages overall External Manufacturing budget and spent, carefully balancing risk and cost
  • Responsible for external GMP warehouse and storage facilities for cell lines and virus banks, DS and DP, and the overall Supply Chain network for clinical trial material distribution
  • As member of CMC team meeting, provide estimates for the resources, cost, timeline tasks, and alternative options to accomplish desired schedule
  • Coordinate the interaction of the CMC cross-functional projects among Voyager personnel, and between Voyager and the CMOs.
  • Work closely with CMOs used to produce GMP material, using site visits and frequent communication with CMO team members to update status of CMC project
  • Interact with program core teams to ensure alignment of CMC plan with overall program strategy, and the requirements of pre-clinical and clinical teams
  • Monitor scope, milestones, dependencies, and costs associated with CMO project and the timelines for CMO deliverables.
  • Drive projects through project goals to ensure compliance to defined schedule.
  • Interact with finance to appraise them of changes in cost and assignment of work orders to specific functions and tasks
  • Create and maintain comprehensive risk management plan for product production
  • Working with the CMC team, provide effective mitigation and escalation strategies for project risks and CMC issues.
  • Manage short and long-term project commitments to supply of drug substance and drug product and communicate levels to internal project teams.
  • Develop and update standard external CMC plans, based on process and historical data, to provide guidance on cost and FTEs required to manage and produce GMP material for new Development projects
  • Manage transition of CMC project from research to development and from early stage to late stage production at a CMO.
  • Strengthen and maintain relationships with key Voyager project team employees and outside vendors and suppliers of CMC services.
  • Assist in coordinating key vendor and supplier evaluations, particularly those supplying services related to raw material supply, product manufacturing, release, storage, and characterization.
  • Ensure project teams adhere to company and departmental policies, procedures, and standards for storage of data related to product production.

Qualifications

  • Minimum PhD in Chemical Engineering with 10+ experience with processes to make biologics, viral vectors or vaccines, or BS\MS degree in Chemical Engineering with 20+ years of experience with processes making biologics, viral vectors or vaccines
  • Experience with planning and managing CMC aspects of biopharmaceutical development
  • Experience in process development and process transfer, focused on biologics or proteins, viral vectors or vaccines
  • Experience in CMO search, selection and management
  • Experience as person in plant (PIP) for production of biopharmaceutical products
  • Ability to travel ( U.S./ Int’l ) 25-50% of time, particularly when production campaigns are being done
  • Has demonstrated the ability to organize external resources to maximize quality and efficiency. Maintains an overview of the entire process when planning a project, setting both short and long-term goals.
  • Works effectively aligning actions to project targets, milestones, and priorities.
  • Excellent communication skills, with the ability to provide clear and audience-focused descriptions of CMC tasks and issues, and proposed solutions to schedule challenges, all done in an open and honest manner.
  • Able to achieve goals in a timely manner, despite obstacles, by prioritizing tasks and building in contingency planning. Results oriented and demonstrates a focus on getting (business) results.
  • Demonstrated ability to facilitate project team meetings, enhance cross-functional communication, support decision making, influence outcomes, and ensure alignment among internal (and sometimes external) stakeholders.
  • Familiar with current issues and Regulatory requirements related to manufacturing using single use equipment for drug substance and drug product production
  • Familiar with trends and developments in the gene therapy field and able to translate those developments into specific business advantages and risks related to production.
  • Proficiency with Microsoft Office suite (e.g. Word, Excel, PowerPoint, Project, Outlook).
To apply, email careers@voyagertherapeutics.com

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Senior Scientist/Engineer, Process Development (Upstream Focus)

Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.

 

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes is central for establishing successful gene therapy applications.  Voyager is seeking a highly motivated Senior Scientist and/or Engineer to join the Process Development Group with a focus on upstream production.  The qualified candidate will be a leader within the group with a strong background and expertise in cell culture manufacturing of biologics.  Primary responsibilities will include carrying out upstream process development activities for the manufacture of pre-clinical and cGMP grade rAAV products, participating in and leading internal productions, writing appropriate documents and carrying out technology transfer to assorted CMOs, and finally participating in cGMP manufacture person in plant activities.  The ability to independently organize and design experiments, analyze data and report the results of their and other’s work in a concise and well documented manner, and to take the initiative to successfully drive Voyager’s projects and manufacturing process are all important aspects of the position.  

Responsibilities

  • Design, development, and optimization of cell growth, transfection, viral infection, and rAAV manufacturing using shake flasks, small-scale and large-scale bioreactors in an Sf9 / baculovirus production system
  • Assemble, sterilize, prepare, and maintain bioreactors, ancillary materials and equipment for cell culture, viral infection and harvest experiments
  • Perform monitoring of cell viability and growth, cell culture metabolites, and other measurements from cultures
  • Develop protocols for viral genome / capsid production in shake flasks, wave bioreactors and stirred tank bioreactors
  • Generate, manage, and maintain critical methods and data in a highly organized manner
  • Assist with and lead the production of nonclinical materials at Voyager
  • Write various experimental reports, SOPs, batch records, technology transfer documents and participate in authoring relevant regulatory documents
  • Provide support for and lead the transfer of developed protocols and upstream processes to internal and external manufacturing parties
  • Lead innovation, development and optimization of the Voyager upstream platform manufacturing process
  • Lead as Voyager point person for and maintain various external relationships with partners, vendors and CMOs/CROs
  • Highly engaged/ involved, leading the Process Development group’s IP, conference and publication strategy

 

Qualifications

 

  • Degree in chemical engineering, biology, biochemistry, chemistry, biotechnology, or related fields
  • PhD degree in relevant subject matter (e.g. cell culture production of biologics) with 5+ years industrial experience in process development
  • Previous experience working with protein biologics or vaccines is a must, prior experience working with rAAV products desired
  • Proficient with aseptic techniques and the use of shake flasks, wave based bioreactors, and stirred tank bioreactors at various scales
  • Strong desire to learn multiple new techniques and willingness to work as part of and help lead a larger team
  • Significant attention to detail and accuracy in developing, reviewing and following protocols, SOPs, batch records and technology transfer documents
  • Ability to be highly productive in a fluid, fast-paced and teamwork oriented environment
  • Prior experience with tech transferring to a cGMP facility is a must, prior experience working with external CMOs desired
  • Prior experience managing a team, co-ops or direct reports is desired

 

Ref# 18TO-CM002

To apply, email careers@voyagertherapeutics.com

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Director, Patient Advocacy

Voyager Therapeutics is looking for a creative, energetic, compassionate, and clinically oriented person to manage programs, communications, and organizational relationships in patient advocacy.  This individual should be committed to supporting active programs and clinical development efforts within Voyager by building collaborative relationships with foundations and patient organizations. The role will report directly to the CMO and will work closely with multidisciplinary teams.

 The successful incumbent will establish and maintain strong relationships with key patient organizations that will provide:

  • Insight into unmet clinical needs, attitudes toward and understanding of gene therapy and route administration.A keen understanding of patient experience of current medical care including costs and barriers to treatment
  • A collaborative approach to implementation of Voyager’s preclinical and clinical stage programs, and potential commercialized products
  • An understanding of patient experiences broadly and specific perspectives on Voyager clinical studies.
  • Develop and implement a patient advocacy strategy that will support all stages of development in collaboration with key functions including clinical development, regulatory, commercial, medical affairs, market research and communications teams.
  • Develop and implement educational and outreach programs to inform and engage Voyager staff and build strong working relationships with patient groups across the organization.

Responsibilities

Develop and maintain strong relationships with key patient groups, foundations, and non-profit organizations, in the US and targeted international markets.

  • Work with relevant Voyager teams to build partnerships and initiatives with these organizations to support development efforts. These may include:
    • Epidemiology studies
    • Natural history studies and patient registries
    • Biomarker development
    • Recruitment and retention efforts in clinical studies
    • Product profile development
    • Education and communications strategy
    • Patient advisory board planning and implementation
  • Recruit and develop Patient/care giver, opinion leaders to lead and build patient support groups and communities both online and off-line.
  • Contribute patient/provider perspectives in preparation and planning of clinical studies, regulatory efforts, and other relevant initiatives within Voyager.
  • Build involvement of organizations in regulatory and advocacy efforts as appropriate.
  • Maintain and expand Voyager’s network of patient opinion leaders.
  • Coordinate internal Voyager events and education efforts regarding disease knowledge and patient perspective.
  • Maintain outreach efforts to connect with new organizations, including those relevant to new and/or potential programs and to broader areas relevant to Voyager’s mission.
  • Manage company commitment to organizations, including event sponsorships, employee involvement, and communications around ongoing organizational initiatives.

 Minimum Requirements

  • BA/BS degree in science or health related area. Degrees in medicine (MD), nursing (RN), public health (MPH), relevant advanced degree (PharmD, PhD), or significant relevant experience as a genetic counselor or similar medical professional are strongly preferred.
  • Minimum of 7 years in the pharmaceutical, biotechnology or healthcare industry required, with demonstrated ability to cultivate and manage strong relationships with key internal and external stakeholders.
  • Excellent oral and written English communication skills. 
  • Demonstrated strategic and critical thinking skills.
  • Ability to interact externally and internally across functions to support the clinical, scientific, and business strategy.
  • Ability to exercise judgment and address complex problems to create solutions across multiple stakeholders with varying interests and perspectives.

 

 

To apply, email careers@voyagertherapeutics.com

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Director/Senior Director, Antibody Platform (Scientific Leader)

Voyager is seeking a highly motivated scientist and leader with extensive experience in therapeutic antibody discovery and development to contribute to our research team and build the Antibody Platform at the company.

This individual will build and lead a platform effort on antibody discovery and engineering including but not limited to AAV-vectorized antibodies, integrating both internal and external resources.  Incumbent will also play an important role in business development opportunities and ongoing and future partnerships. The candidate should have substantial working familiarity and demonstrated success with state-of-the-art approaches for generating, selecting, humanizing and optimizing human antibodies and antibody fragments against targets of interest. These approaches include tools and systems such as transgenic mouse strains that produce human antibodies, high throughput hybridoma and B-cell cloning from immunized animals and from human samples, and display technologies for affinity maturation. Responsibilities will include the development of a strategy and implementation of plans for rapid advancement of the vectorized antibody platform, and oversight of a group responsible for activities that include hybridoma screening, antibody gene cloning and sequencing, recombinant antibody expression, antibody humanization, lead antibody identification, antibody optimization including affinity maturation, and antibody characterization. This is an ideal position for an individual who is energetic and thrives in a team-oriented, fast-paced, and cross-disciplinary small biotech company environment. This role is located in Cambridge, MA.

Requirements

  • PhD in Immunology, Cell Biology, Molecular Biology, Biochemistry or related fields and with at least 10+ years industry experience, or equivalent
  • Track record of leading successful antibody drug discovery and candidate selection for transition to development
  • In-depth knowledge and expertise with designing workflows for hybridoma screening and antibody gene isolation and characterization
  • Substantial working experience with antibody affinity maturation and humanization methods
  • Outstanding problem-solving skills
  • Ability to be highly productive in a fluid, fast-paced, team-oriented work environment
  • Proven experience with leading and managing a small group, with minimum of 7 years in a leadership and supervisory role in industry
  • Experience on cross-functional therapeutic program team
  • Outstanding organizational skills
  • Extensive experience working with CROs
  • Strong publication record and experience in presenting research

Strongly Preferred

  • Experience with drug discovery for neurodegenerative diseases
  • Experience within a start-up or small biotech environment

 

To apply, email careers@voyagertherapeutics.com

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To apply or learn more about career opportunities at Voyager Therapeutics, please email careers@voyagertherapeutics.com.

Note to Employment Agencies: Please do not forward agency resumes. Voyager Therapeutics is not responsible for any fees related to resumes that are unsolicited and out of executed contracts.

Voyager Therapeutics will only accept job applications from candidates who are properly documented with authorization to work in the United States.

Equal Opportunity Employer M/F/D/V