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Voyager is looking for exceptional individuals who share our passion for developing life-changing gene therapies for severe neurological diseases.

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Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Huntington’s disease, Friedreich’s ataxia, Alzheimer’s Disease and neuropathic pain.

The Antibody Platform group at Voyager Therapeutics is looking for a highly motivated individual experienced in antibody discovery and engineering, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment.  The individual will be responsible for activities that include culture and cloning of hybridomas for monoclonal antibody production and characterization, screening of hybridoma clones, antibody V gene sequencing, and recombinant antibody expression, purification, and characterization.  This position is located in Cambridge, MA.

Experience/Qualifications:

  • BA/BS or MS with a strong background in protein biochemistry, molecular biology, cell biology, or related field (with 2+ years of relevant laboratory experience in a biotech setting)
  • Substantial hands-on experience with protein binding assays (ForteBio Octet, Biacore, ELISA, flow cytometry) and developability assessment (CIC, AC-SINS, BV ELISA) preferred
  • Significant hands-on experience with transient and stable expression of proteins in HEK293 and CHO cells
  • Hands-on experience in antibody and/or protein purification (affinity, ion exchange, SEC) methodology
  • Experience with antibody sequence isolation, repertoire analysis, and V region classification is highly desired
  • Excellent communication skills, written and verbal
  • Strong commitment and accountability for completion of projects in accordance with team plans
  • Excellent organizational skills and attention to detail

Strongly preferred:

  • Significant experience with early drug development within a small biotech environment
  • Significant experience working within a cross-functional therapeutic program team
  • Familiarity with hybridoma or display technologies (phage-display, yeast display, etc.)
To apply, email careers@voyagertherapeutics.com

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Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Huntington’s disease, Friedreich’s ataxia, Alzheimer’s Disease and neuropathic pain.

The Antibody Platform group at Voyager Therapeutics is looking for a highly motivated individual experienced in antibody discovery and engineering, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment.  The individual will be responsible for activities that include the design of antibody discovery and optimization campaigns, developing biochemical and cell-based screening assays for antibody therapeutic lead selection, screening of antibodies from hybridoma and display campaigns, antibody V gene sequencing, and recombinant antibody expression, purification, and characterization.  This position is located in Cambridge, MA. 

Experience/Qualifications:

  • PhD in molecular biology, biochemistry, protein/antibody engineering, immunology, or related field with 0-3 years postdoctoral biologics experience preferred, or BS/MS with 7+ years of relevant experience
  • Ability to collaborate with Biology and Vector Engineering colleagues to generate appropriate in vitro, cellular, and in vivo data packages supporting PoC
  • Substantial hands-on experience with protein binding assays (ForteBio Octet, Biacore, ELISA, flow cytometry) and developability assessment (CIC, AC-SINS, BV ELISA)
  • Hands-on experience with transient and stable expression of proteins in HEK293 and CHO cells
  • Significant hands-on experience in antibody and/or protein production (small scale) and purification (affinity, ion exchange, SEC) methodology
  • Extensive experience with antibody sequence isolation, repertoire analysis, and V region classification
  • Outstanding problem-solving skills and ability to multi-task
  • Excellent communication skills, written and verbal
  • Ability to independently analyze and present data to scientific teams
  • Strong commitment and accountability for completion of projects in accordance with team plans
  • Excellent organizational skills and attention to detail

Strongly preferred:

  • Significant experience with early drug development within a small biotech environment
  • Proven record in antibody engineering, humanization and affinity maturation
  • Significant experience working within a cross-functional therapeutic program team
  • Strong publication record in peer-reviewed journals
To apply, email careers@voyagertherapeutics.com

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Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the nervous system. Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Huntington’s disease, Friedreich’s ataxia, Alzheimer’s Disease and neuropathic pain.

Voyager Therapeutics seeks a highly motivated and experienced molecular biologist to contribute to its research team at its facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in early protein drug development (especially AAV gene therapy), who has a can-do attitude and strong work ethic, and thrives in a team-oriented, fast-paced, and cross-disciplinary small biotech environment.

Responsibilities: 

  • Responsible for experimental design, execution, data analysis and reports (both written and verbal) for AAV platform discovery research as well as therapeutic programs
  • Conduct studies in-house and with collaborators and to manage studies conducted at contract research organizations
  • Extensive prior hands-on expertise in molecular and cellular techniques, and significant experience with lead identification/optimization are required

Requirements:

  • Master’s Degree and a minimum of 5 years of work experience OR a Ph.D and a minimum of 0-3 years of work experience in Molecular/Cellular Biology or related 
  • Hands-on experience in drug discovery research, including biologics or gene therapy
  • Extensive hands-on experience with molecular and cellular techniques
  • Proven track record in lead discovery/optimization
  • Significant experience with managing and maintaining collaborations with other laboratories and/or CROs
  • Outstanding problem solving skills
  • Ability to be highly productive in a fluid, fast-paced team environment 

Preferred:

  • Significant experience with early drug development within a small biotech environment
  • Proven track record in antibody/protein engineering, production (small scale) and purification
  • Significant experience with cross-functional therapeutic program teams
  • Working knowledge of RNAi and artificial miRNA construction, optimization and evaluation
  • Experience with writing industry study reports (reports in support of IND a significant plus)
  • Strong publication record in peer-reviewed journals
To apply, email careers@voyagertherapeutics.com

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Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy, expressed RNA interference and neuroscience. Our management team has deep expertise and a track record of building exceptional life science companies.

Voyager Therapeutics is seeking an Associate Director, Clinical operations, who is an exceptional, experienced, and high energy individual with significant clinical drug development knowledge of early and late phase trials to help build a high performing team and growing department. This individual will be responsible for implementing the strategic plans for Clinical Operations and overseeing Clinical Operations staff in the conduct of Phase I-IV clinical trials across multiple therapeutic areas in accordance with GCP, CFR, and ICH regulations. This position reports to the Director of Clinical Operations.

Responsibilities

  • Responsible for development of clinical operations strategic plans, overall study budgets (including forecasts and accruals) and timelines for assigned clinical programs including tactical execution in accordance with Company goals, objectives, and budget
  • Partner with Medical Director and Program Team Lead to develop and implement Clinical Development Plan (CDP) and function as Sr. Clinical Operations Lead on internal Program Team
  • Provide clinical operations leadership and comprehensive oversight to all operations functions and Clinical Trial Managers under assigned clinical programs
  • Partner with Clinical Trial Manager and other functional areas within Voyager, CROs, and third-party vendors to ensure clinical trials are executed on time and within established budget
  • Play a key role in oversight of CRO partners and other vendors, functioning as the escalation point for issues/risks to Sr. Management, including risk mitigation/remediation plans
  • Support Clinical Trial Manager with identification of potential vendors, development of RFPs, scope of service agreements and/or change orders
  • Develop strong relationships with investigators and site staff, and ensure study is conducted in accordance with established company processes and SOPs
  • Contribute to departmental resourcing and recruitment plans to ensure proper timing and allocation of resources to clinical studies to achieve study timelines and deliverables
  • Directly manage staff (Clinical Trial Managers, Clinical Trial Associates) with responsibility for staff training and mentoring, performance management, setting individual employee goals and career growth opportunities for staff. Also lead FSP and contract staff who may be remote to Voyager’s offices.
  • Collaborate with Director of Clinical Operations to define and monitor key performance indicators and departmental metrics, as well as identification of opportunities for process optimization, training needs, and procedures (SOPs, Work Instructions)
  • Participate in departmental and cross-functional process improvement initiatives, often as initiative or workstream leader
  • Champion best practice development in planning, conduct, and reporting of clinical studies and sharing knowledge/information to support innovation and efficiencies across study teams
  • Contribute to development of departmental goals and objectives to achieve corporate goals
  • Ensure timely and clear communication to staff on updates, progress, decisions from Sr. Management

Qualifications:

  • A minimum of a Bachelor’s degree in science or related field is required
  • Advanced degree (i.e. Master’s, PhD, PharmD, etc.) preferred
  • A minimum of 10 years of significant work experience in the biopharmaceutical industry, with experience executing clinical trials globally across all phases of development
  • Exceptional leadership and interpersonal skills with an ability to effectively work and identify resolutions to challenges within a multidisciplinary team and to effectively lead external vendors/CROs
  • Significant experience with line management of employees
  • Consistent track record of successfully leading staff to deliver clinical trials on time, on budget and with quality while ensuring inspection readiness
  • Demonstrated adaptability, flexibility, independence and resourcefulness to thrive in a small-sized. Fast-paced company environment
  • Excellent organizational, written communication, and presentation skills
  • Excellent oral and written communications.
  • Strong understanding of GCP, CFR and ICH guidelines
  • Proficient computer skills including knowledge of Microsoft Excel, Word, Powerpoint, Project, and Outlook.
  • Prior CNS or gene therapy experience preferred.
  • Travel up to 15% as needed (Domestic/ Int’l)
To apply, email careers@voyagertherapeutics.com

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Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the nervous system. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy. Our management team has deep expertise and a track record of building exceptional life science companies.

We are currently seeking an experienced and highly motivated Associate Director / Director in the Neuroscience Department within Research who shares our passion for the promise of gene therapy to transform the treatment of CNS diseases. The successful candidate will work with our multidisciplinary team in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in CNS drug development, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment.

Responsibilities:

  • Lead scientific projects / programs, and contributions to multiple pre-clinical gene therapy programs
  • Lead a team of biologists including PhD level scientists with a focus on in vivo and ex vivo studies and analysis
  • Contribute to the identification and implementation of new pipeline programs
  • Design studies for pre-clinical development and generate reports for regulatory submissions
  • Manage external collaborations and research studies

Requirements:

  • PhD or equivalent degree in the field of biology, pharmacology, or related discipline
  • A minimum of 10 years of industry experience in biotech/pharma drug development or equivalent
  • Extensive experience and demonstrated scientific leadership in neurodegenerative or neurological disease research and drug development
  • Experience in managing small drug discovery/research teams
  • Significant experience with in vivo pharmacology and efficacy studies using models of neurodegenerative disease
  • Drug discovery/pharmacology experience with gene therapy and viral vectors
  • Familiarity with patent applications and in-licensing efforts
  • Experience with clinical translation is highly preferred
  • Experience in program/project leadership including project plan generation, time line management and budget planning
  • Strong verbal and written communication skills and capable of routinely and concisely presenting study results and implications
  • Proactive, highly organized, flexible, independent, and able to thrive in a fast-paced team environment
  • Outstanding team player who is able to work effectively across departments and comfortable working on and prioritizing multiple projects at once
To apply, email careers@voyagertherapeutics.com

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Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy, expressed RNA interference and neuroscience. Our management team has deep expertise and a track record of building exceptional life science companies.

Voyager Therapeutics seeks an experienced and highly motivated biologist to contribute to its research team at its facility in Cambridge, Massachusetts. This is a hands-on position for a person committed to helping the group conduct innovative drug discovery research while meeting deadlines and company goals. We are seeking a person who is enthusiastic about biomedical research, is capable of working independently, as well as collaboratively with other scientists and team members. This is an ideal position for an individual with a strong background in tissue processing, histology, in-situ-hybridization, special stains, and immunohistochemistry methods, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. Experience in automated image analysis, multiplexed immunohistochemistry, in-situ-hybridization, and laser capture microdissection is highly desirable.  Knowledge of neuroanatomy would be a plus. The candidate should also be able to independently execute experiments and have good communication and interpersonal skills.

Requirements:

  • S./ M.S.in life sciences or related field
  • A minimum of 1-3 years of hands-on experience with excellent tissue handling, histology and immunohistochemistry techniques
  • In situ hybridization and laser capture microdissection experience strong plus
  • Self-motivated, able to work independently, highly organized with strong attention to detail
  • Good communication and presentation skills

 Strongly Preferred:

  • Experience with automated tissue processing (e.g. Leica Bond system) a plus
  • Digital pathology experience such as brightfield and fluorescence image acquisitions using whole slide scanners and image analysis using Aperio, Halo or Visiopharm would be a plus
  • Basic knowledge of neuroanatomy and neuroscience
  • Basic necropsy skills a plus
  • Existing experience in pharmaceutical/ biotechnology industry
  • Experience in cross-functional therapeutic program team
  • Experience within a start-up or small biotech environment

Key responsibilities for this position include, but are not limited to:

  • Develop, validate and execute single or multiplex IHC/ISH assays with fresh frozen or fixed CNS and peripheral tissues with chromogenic and Immuno-fluorescence methods to characterize the expression of transgenes and distributio of adeno-associated gene therapy virusesin tissues from different species.
  • Coordinate the workflow in histology to meet project and company goals
  • Prepare animal specimens for histology analyses including fixation, processing, embedding, microtomy and routine/special/IHC staining.
  • Effectively and independently perform routine histology instrument operations with working knowledge of maintenance and troubleshooting.
  • Perform routine/special stains for CNS tissues to evaluate neuronal cell death and degeneration in CNS tissues
  • Execute and troubleshoot standard protocols, adapt new protocols into practice with little assistance, and query literature to incorporate additional assays as needed
  • Analyze the data and present results from studies to the group/team and train others in histology

QC

To apply, email careers@voyagertherapeutics.com

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Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases.  Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.
 
Overview: 
Voyager has an exciting semester long, full-time Co-op opportunity.  The main goal of the project is to explore the use of AAV-specific antibodies as an analytical tool for the quantitation of viral capsids. Since anti-AAV single chain antibodies are available both in biotinylated form, suitable for use coupled to biosensors, and crosslinked to chromatography resins, the evaluation of two alternative quantitation techniques will constitute two distinct sub-goals of the project. The first will explore the use of Surface Plasmon Resonance; the second will look at the development of an HPLC-based method.
A fast, reliable, and high-throughput method for viral capsid titer would benefit all of the Company’s programs, and the candidate would gain experience in analytical and biophysical method development in one of the fastest moving fields of drug development.
  
Qualifications and Learning Objectives: 
The ideal candidate is a 3rd or 4th year student majoring in Biochemistry, Chemistry, or Biology, with at least some prior experience in the use of chromatography and/or biophysical techniques used to detect and measure biomolecular interactions. An enthusiastic attitude and desire to learn, coupled with a good understanding of the principle of biochemistry is essential
The intern would be provided with mentorship and training in various techniques, including HPLC and SPR, and would have the opportunity to learn basic industry skills such as experimental planning, data analysis, interdepartmental presentations and effective documentation.

The supervisor will define the general project goals and will meet weekly with the candidate to discuss data and results, to plan future experiments, and to provide overall guidance.
 
 Evaluation and Project Completion: 
The project will be evaluated based on the progress made on the goals outlined in the description, in accordance to the timeline provided. The completion of the project would entail the development of alternative methods, if feasible, for quantitation of viral capsids making use of HPLC and SPR, together with an in-depth comparison of the strengths and weakness of each of them.
As a member of Analytical Development, the intern would be presenting regular updates and receive feedback both in analytical development meetings and in meetings to a wider tech ops audience. The outcome of the project will be shared in a final presentation at the end of the internship.
 

To apply, email careers@voyagertherapeutics.com

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Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases.  Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.
 
Overview:
Voyager has an exciting semester long, full-time Co-op opportunity. The selected candidate will work on addressing this future concern by developing high productivity processes. The goals of this project is to identify and study the impact of Sf9 specific, production boosting additives on AAV productivity and quality; optimization of an AAV production process to meet pre-clinical and clinical product demand.
The individual will gain a deep understanding about upstream process development. He/She will learn new and developing technologies in the gene therapy space, such as perfusion and gene vector production using baculovirus system. They will also learn how upstream process development collaborates with other functional groups to contribute towards CMC development of gene therapy pipeline
 
Qualifications:

  • 2+ years in an engineering or sciences degree program (Juniors or Seniors)
  • Good aseptic techniques. Experience working with cell culture is preferred.
  • Comfortable using MS office tools (Excel, Word, PowerPoint, etc.)

 
Learning Objectives:

  • Learn how to work with insect cells, maintain and grow cell cultures.
  • Learn bioreactor operations and understand important considerations for biologics production.
  • Data analytics and learn how to design multivariate/univariate experiments.
  • Opportunity to present their work progress at internal group meetings

 Evaluation and Project Completion:

Project’s progress and the intern’s development will be evaluated regularly through frequent meetings with supervisor and presentations during internal group meetings
On project completion, the selected intern would be expected to present his/her work and findings to a larger internal audience via a poster or oral presentation. 

To apply, email careers@voyagertherapeutics.com

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Senior Research Associate/Principal Research Associate

Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the nervous system. Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Huntington’s disease, Friedreich’s ataxia, Alzheimer’s Disease and neuropathic pain.

We are currently seeking an experienced and highly motivated Senior Research Associate or Principal Research Associate who shares our passion for the promise of gene therapy. The successful candidate will work with our multidisciplinary team in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in preclinical rodent in vivo experiments, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment.

Responsibilities:

  • The individual will be responsible for experimental execution and data analysis for research studies supporting therapeutic programs and platform discovery research.
  • Performing test article dosing via various administration routes, brain and tissue collection, and downstream analysis (RT-qPCR, western blot and ELISA).
  • Design and execute rodent in vivo experiments including experiments in animal models of neurodegenerative disease
  • Performing data analyses and delivering data presentation to teams
  • Ensuring maintenance of industry-quality records and proper documentation
  • Monitor health, perform behavioral assessments and tissue/blood collection

Requirements:

  • A Bachelor’s Degree with a minimum of 8-10 years of experience OR a Master’s degree with a minimum of 5-8 years of experience
  • A minimum of 5 years of hands-on experience with performing test article administration in rodent (mouse and rat)
  • Experience in neuroscience is required
  • Technical proficiency with a wide variety of rodent in vivo pharmacology skills (IV, IP, IM)
  • The successful candidate will have extensive prior experience in drug discovery and in neurodegenerative diseases.
  • Conducting ex vivo tissue analysis (i.e. ELISA, western blot, RT-qPCR.)
  • Outstanding problem-solving skills and ability to multi-task
  • Self-motivated, able to work independently, highly organized with strong attention to detail
  • Competency with database, spreadsheet and presentation applications (i.e. Excel, PowerPoint, Data entry systems, or similar)

2MG

To apply, email careers@voyagertherapeutics.com

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Scientist I, Neuroscience

Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the nervous system. Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Huntington’s disease, Friedreich’s ataxia, Alzheimer’s Disease and neuropathic pain.

We are currently seeking an experienced and highly motivated Scientist I who shares our passion for the promise of gene therapy. The successful candidate will work with our multidisciplinary team in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in neurodegeneration, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment.

Responsibilities:

  • The individual will oversee external collaborations with academic labs/CROs
  • S/he will directly work at the bench and be responsible for development and implementation of a variety of assays supporting therapeutic programs and platform discovery research
  • This individual will have extensive prior experience assessing CNS pharmacological readouts including biochemical assay development and implementations (ELISA, LC-MS, RT-qPCR, etc.)

Requirements:

  • A Master’s degree with a minimum of 8 years of experience or a PhD in the field of biology or related discipline is required
  • Extensive experience in all aspects of assay design, development, optimization, validation, and implementation to support gene therapy discovery programs (i.e. RT-qPCR, LC-MS, and ELISA)
  • In vitro skills including general molecular and cellular biology methods, cell-based assays and ex vivo tissue analysis from animal models
  • Current on relevant published literature and developments in the field
  • Proactive, flexible, and able to thrive in a fast-paced team environment
  • Comfortable working on and prioritizing multiple projects
  • Strong verbal and written communication skills and capable of routinely interpreting data and making presentations to diverse groups within Research and Development

 Preferred:

  • Knowledge of assay development in context of preclinical PK-PD evaluation
  • Drug discovery/pharmacology experience with gene therapy and viral vectors
  • Experience with preclinical animal studies including design and execution of test article dosing via various administration routes and sample collection
  • Demonstrated scientific leadership, and strong interpersonal and coaching skills through team roles and mentoring of scientists
  • Work experience within a cross-functional and matrixed organization and/or a highly collaborative research environment

MG

To apply, email careers@voyagertherapeutics.com

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Scientist, Neurobiology (In-Vivo)

Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Huntington’s disease, Friedreich’s ataxia, Alzheimer’s Disease and neuropathic pain.

We are seeking an experienced and highly motivated neurobiologist to contribute to our research team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in in vivo experimental methods and readouts, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental execution and data analysis for research studies supporting therapeutic programs and platform discovery research in neurodegenerative disease areas.  The successful candidate will have extensive prior experience in drug discovery in neurodegenerative diseases including hands-on techniques in stereotaxic surgery, in vivo behavioral assays of rodent models, CNS tissue dissection, and tissue analysis (such as RT-qPCR, western blot and ELISA). 

This position is located in Cambridge, MA and reports to a Senior Scientist.

Responsibilities:

  • Drive the planning, design and execution of rodent in vivo experiments
  • Perform rodent in vivo studies including dosing, in-life assessments and tissue analysis (ELISA, western blot, RT-qPCR, immunohistochemistry, etc.)
  • Perform data analyses and deliver data presentations to the research team
  • Ensure maintenance of industry-quality records to provide documentation

Requirements:

  • PhD (1-3 years) or MS (+ 5 years) experience in neuroscience or related discipline
  • Hand-on experience with performing survival surgeries including stereotaxic or direct intraparenchymal injection and rodent behavioral testing to assess motor dysfunction
  • Outstanding problem-solving skills and ability to multi-task
  • Molecular and cell biology experience
  • Excellent communication skills, written and verbal
  • Ability to independently analyze and present data to scientific teams
  • Strong commitment and accountability for completion of projects in accordance with team plans
  • Excellent organizational skills and attention to detail

Strongly Preferred:

  • Experience on cross-functional therapeutic program teams
  • Experience within a start-up or small biotech environment
  • Experience with drug discovery for neurodegenerative diseases, particularly tau-related diseases

2WL

To apply, email careers@voyagertherapeutics.com

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Research Associate, Biology (In-Vivo)

Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Huntington’s disease, Friedreich’s ataxia, Alzheimer’s Disease and neuropathic pain.

We are seeking a highly motivated biologist to contribute to our research team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with experience in in vivo and ex vivo methods, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental execution for research studies supporting cutting edge therapeutic programs and platform discovery research in neurodegenerative disease areas.   We are looking for a candidate with hands-on experience with rodent in vivo studies (dosing and tissue collection) and downstream analysis (e.g. RT-qPCR, ELISA, tissue sectioning, immunohistochemistry and western blot).

This position is located in Cambridge, MA and reports to a Research Scientist.

Requirements:

  • A minimum of a Bachelor’s Degree in Biology (or related discipline) is required
  • A Master’s Degree in Biology (or related discipline) preferred
  • Professional work experience in biotechnology, pharmaceutical, life sciences, or similar industry experience is preferred
  • Hands-on experience with rodent handling, tissue dissection and data analysis
  • Experience with design, documentation and execution of experiments
  • Outstanding problem-solving skills
  • Willingness to learn new laboratory techniques
  • Ability to be highly productive in a fluid and fast-paced work environment

Strongly Preferred:

  • Familiarity with stereotaxic brain injections and CNS tissue dissections
  • Familiarity with molecular and biochemical methods, such as PCR, ELISA, western, and immunohistochemistry
  • Experience within a start-up or small biotech environment

1GM

To apply, email careers@voyagertherapeutics.com

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Associate Director/Director, Regulatory Affairs

The Company

Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.

 The Position

This position will report to the Vice President of Regulatory Affairs. As the Associate Director/Director of Regulatory Affairs, you will be responsible for development and implementation of regulatory strategy for assigned projects, serving as the regulatory lead on project teams, and serving as the regulatory contact with regulatory authorities.

Responsibilities:

  • Serve as the regulatory lead on project teams with expertise in U.S. and EU regulatory affairs
  • Develop and implement regulatory strategy for assigned projects in all stages of development (pre-IND/pre-CTA through approval and life-cycle management)
  • Project manage regulatory deliverables coordinating all aspects of regulatory submissions for assigned projects
  • Author regulatory documents in support of filings including INDs/CTAs, Briefing Materials, and BLAs/MAAs
  • Work collaboratively on cross-functional teams taking a problem-solving approach
  • Identify regulatory risks and provide proposals for risk mitigations
  • Prepare and deliver effective presentations for external and internal audiences
  • Lead interactions with regulatory agencies
  • Ability to work both independently with minimal direction and within project teams, committees, etc. to attain group goals
  • Mentor other Regulatory staff members

Qualifications

  • A minimum of a Bachelor’s degree required
  • Advanced scientific degree preferred (i.e. MS, PharmD, PhD, etc.)
  • A minimum of 8 years of pharmaceutical/biotechnology industry experience and 5 years in regulatory affairs
  • Experience working on products in development specifically relating to clinical and nonclinical regulatory aspects of the project
  • Experience in interfacing with relevant regulatory authorities
  • Experience and knowledge in the preparation of major regulatory submissions and supportive amendments or supplements
  • Experience in interpretation of regulations, guidelines, policy statements, etc.
  • Knowledge of GCPs and GLPs
  • Excellent communication (written and verbal) and influencing skills
  • Strong organizational skills, including the ability to prioritize workload
  • Strong interpersonal skills and the ability to deal effectively with a variety of personnel including medical, scientific, and manufacturing staff.
  • Strategic thinking, change agent leadership and risk assessment, including ability to integrate overall business objectives into the goals/vision/values of department and communicate these effectively, Specifically, an ability to provide viable approaches to problem-solving based upon an ability to interpret current Regulations and Guidances for unique applications for innovative gene therapy products

1MS

To apply, email careers@voyagertherapeutics.com

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 Manager, Lab Operations

 Voyager Therapeutics is a clinical-stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease and spinal muscular atrophy (SMA). Voyager has broad strategic collaborations with Sanofi Genzyme, the specialty care global business unit of Sanofi, and the University of Massachusetts Medical School. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy, expressed RNA interference and neuroscience. Our management team has deep expertise and a track record of building exceptional life science companies.

 Voyager is seeking a highly motivated and experienced Manager, Lab Operations to provide support functions to ensure a smooth progression of our research programs and scientific staff at multiple locations in Cambridge. The primary responsibilities require a high level of customer service, while delivering strategic and tactical execution of lab operations. The ideal candidate will be responsible for, but not limited to scientific staff support, purchasing & inventory management, equipment/maintenance, metrology and vendor management. The successful candidate will embrace change, innovation and initiate process improvements by creating sustainable, value – add propositions.

Responsibilities: 

  • Demonstrated experience establishing/negotiating and managing/supervising effective relationships with range of external vendors and service providers, including on-site contract personnel
  • Manage/oversee the maintenance and repair of laboratory equipment, including daily upkeep, routine quality control and troubleshooting, and scheduling of preventive maintenance
  • Serve as the primary contact for equipment maintenance/repair and all purchasing activities for Capital expenses, consumable orders and ample stock of lab reagents
  • Identify and implement continuous improvement projects.
  • Partner with EHS to ensure safe working environment for all scientific staff
  • Develop and maintain accurate and user-friendly inventory management program
  • Work with Finance to track and manage capital assets
  • Assist internal and external audits and inspections
  • Lead management of alarm systems, including restoration and routine checks
  • Manage storage and pick up for all lab waste
  • Establish and document industry best practices, negotiate schedules and contracts to maximize efficiencies
  • Coordinate daily/weekly shipping/receiving activities to include BL2 samples
  • Collaborate effectively with peers, stakeholders and partners across the organization to positively impact business results

Requirements: 

  • Bachelor’s degree highly preferred
  • A minimum of 5 – 8 years of experience either in an academic or industry setting; or equivalent combination of education, training and experience
  • Experience interacting with various regulatory agencies
  • Proficiency with computer-based data management and Microsoft Office is required. Knowledge of LIMS, CMMS, BioProcure, Oracle systems a plus
  • IATA Shipping Certifications and/or Wastewater Treatment Grade 2 license a plus

Additional Skills:

  • Outstanding customer service and attention to detail is required
  • Ability to see tasks through to completion, deliver successful results, and instill confidence across the organization is vital
  • Excellent organization, written and verbal communication skills
  • Ability to work well within a fast-paced environment across multi-disciplinary teams
  • Strong multi-tasking and sound time management skills
  • Live Voyager’s core values of Passion, Pioneering, Integrity and Collaboration in every aspect of his/her work life
To apply, email careers@voyagertherapeutics.com

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Senior Scientist/Engineer – Upstream Process Development

Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes is central for establishing successful gene therapy applications.  Voyager is seeking a highly motivated Senior Scientist and/or Engineer to join the Upstream Process Development Group.  The qualified candidate will be a leader within the group with a strong background and expertise in cell culture manufacturing of biologics.  Primary responsibilities will include carrying out upstream process development activities for the manufacture of pre-clinical and cGMP grade rAAV products, participating in and leading internal productions, writing appropriate documents and carrying out technology transfer to assorted CMOs, and finally participating in cGMP manufacture person in plant activities.  The ability to independently organize and design experiments, analyze data and report the results of their and other’s work in a concise and well documented manner, and to take the initiative to successfully drive Voyager’s projects and manufacturing process are all important aspects of the position.  

Responsibilities

  • Design, development, and optimization of cell growth, transfection, viral infection, and rAAV manufacturing using shake flasks, small-scale and large-scale bioreactors in an Sf9 / baculovirus production system
  • Assemble, sterilize, prepare, and maintain bioreactors, ancillary materials and equipment for cell culture, viral infection and harvest experiments
  • Perform monitoring of cell viability and growth, cell culture metabolites, and other measurements from cultures
  • Develop protocols for viral genome / capsid production in shake flasks, wave bioreactors and stirred tank bioreactors
  • Generate, manage, and maintain critical methods and data in a highly organized manner
  • Assist with and lead the production of nonclinical materials at Voyager
  • Write various experimental reports, SOPs, batch records, technology transfer documents and participate in authoring relevant regulatory documents
  • Provide support for and lead the transfer of developed protocols and upstream processes to internal and external manufacturing parties
  • Lead innovation, development and optimization of the Voyager upstream platform manufacturing process
  • Be the Voyager point person for and maintain various external relationships with partners, vendors and CMOs/CROs
  • Be highly involved with and help lead the Process Development group’s IP, conference and publication strategy

Qualifications

  • Degree in chemical engineering, biology, biochemistry, chemistry, biotechnology, or related fields
  • PhD degree in relevant subject matter (e.g. cell culture production of biologics) with 5+ years industrial experience in process development
  • Previous experience working with protein biologics or vaccines is a must, prior experience working with rAAV products desired
  • Proficient with aseptic techniques and the use of shake flasks, wave based bioreactors, and stirred tank bioreactors at various scales
  • Strong desire to learn multiple new techniques and willingness to work as part of and help lead a larger team
  • Significant attention to detail and accuracy in developing, reviewing and following protocols, SOPs, batch records and technology transfer documents
  • Ability to be highly productive in a fluid, fast-paced and teamwork oriented environment
  • Prior experience with tech transferring to a cGMP facility is a must, prior experience working with external CMOs desired
  • Prior experience managing a team, co-ops or direct reports is desired
To apply, email careers@voyagertherapeutics.com

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Senior Associate Scientist / Engineer – Upstream Process Development

Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes is central for establishing successful gene therapy applications.  Voyager is seeking a highly motivated Sr. Associate Scientist / Engineer to join the Upstream Process Development group.  The qualified candidate will carry out process development activities for the manufacture of pre-clinical and cGMP grade rAAV products.  In addition, the candidate will also participate in internal production activities, writing appropriate documents, assisting with technology transfer activities, and participating in cGMP manufacture person in plant activities. The ability to independently organize and design experiments, analyze data and report the results of their work in a concise and well documented manner are important aspects of the position. 

Responsibilities

  •  Design, development, and optimization of cell growth, transfection, viral infection, and rAAV manufacturing using shake flasks, small-scale and large-scale bioreactors in an Sf9 / baculovirus production system
  • Assemble, sterilize, prepare, and maintain bioreactors, ancillary materials and equipment for cell culture, viral infection and harvest experiments
  • Perform monitoring of cell viability and growth, cell culture metabolites, and other measurements from cultures
  • Develop protocols for viral genome / capsid production in shake flasks, wave bioreactors and stirred tank bioreactors
  • Generate, manage, and maintain critical methods and data in a highly organized manner
  • Assist with and lead the production of nonclinical materials at Voyager
  • Write various experimental reports, SOPs, batch records, technology transfer documents and participate in authoring relevant regulatory documents
  • Provide support for and lead the transfer of developed protocols and upstream processes to internal and external manufacturing parties

Qualifications 

  • Bachelor’s or Master’s degree in chemical engineering, biology, biochemistry, chemistry, biotechnology, and related fields
  • Minimum B.S. degree with 3+ years of relevant industrial experience or a M.S. degree in relevant subject matter (e.g. cell culture production of biologics) with 2+ years of industrial experience
  • Previous experience working with protein biologics or vaccines is a must, prior experience working with AAV and/or in a process development group is desired
  • Technical proficiency and experience for aspects of cell line growth optimization and production of biological products using bioreactors is required
  • Strong desire to learn multiple new techniques and willingness to provide support to more senior research personnel as required
  • Significant attention to detail and accuracy in developing and following protocols
  • Ability to be highly productive in a fluid, fast-paced and teamwork environment
To apply, email careers@voyagertherapeutics.com

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Scientist / Engineer – Upstream Process Development

Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes is central for establishing successful gene therapy applications.  Voyager is seeking a highly motivated Scientist / Engineer to join the Upstream Process Development group.  The qualified candidate will carry out process development activities for the manufacture of pre-clinical and cGMP grade rAAV products.  In addition, the candidate will also participate in internal production activities, writing appropriate documents, assisting with technology transfer activities, and participating in cGMP manufacture person in plant activities. The ability to independently organize and design experiments, analyze data and report the results of their work in a concise and well documented manner are important aspects of the position. 

Responsibilities

  •  Design, development, and optimization of cell growth, transfection, viral infection, and rAAV manufacturing using shake flasks, small-scale and large-scale bioreactors in an Sf9 / baculovirus production system
  • Assemble, sterilize, prepare, and maintain bioreactors, ancillary materials and equipment for cell culture, viral infection and harvest experiments
  • Perform monitoring of cell viability and growth, cell culture metabolites, and other measurements from cultures
  • Develop protocols for viral genome / capsid production in shake flasks, wave bioreactors and stirred tank bioreactors
  • Generate, manage, and maintain critical methods and data in a highly organized manner
  • Assist with and lead the production of nonclinical materials at Voyager
  • Write various experimental reports, SOPs, batch records, technology transfer documents and participate in authoring relevant regulatory documents
  • Provide support for and lead the transfer of developed protocols and upstream processes to internal and external manufacturing parties

Qualifications

  •  Bachelors, Masters or Ph.D. degree in chemical engineering, biology, biochemistry, chemistry, biotechnology, and related fields
  • Minimum experience:
    • S. degree with 8+ years of relevant industrial experience
    • S. degree in relevant subject matter (e.g. cell culture production of biologics) with 7+ years of industrial experience
    • D. degree in relevant subject matter (e.g. cell culture production of biologics)
  • Previous experience working with protein biologics or vaccines is a must, prior experience working with AAV and/or in a process development group is desired
  • Technical proficiency and experience for aspects of cell line growth optimization and production of biological products using bioreactors is required
  • Strong desire to learn multiple new techniques and willingness to provide support to more senior research personnel as required
  • Significant attention to detail and accuracy in developing and following protocols
  • Ability to be highly productive in a fluid, fast-paced and teamwork environment
To apply, email careers@voyagertherapeutics.com

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Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases.  Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.

Voyager is seeking a highly motivated leader to manage its expanding Analytical Development team.

The qualified candidate will be a leader within Voyager Technical Operations with a strong background and expertise in analytical development for biologics or vaccines.

Primary responsibilities will include oversee the scientific development, qualification, transfer and execution of new state-of-the-art analytical methods to be used for release and characterization of Voyager’s clinical and commercial products. This individual will also manage the team responsible for process assay support to other Development groups within the company. Ability to lead and provide guidance to a growing team of over 10 scientists is required.

Additionally, the individual will key leader in the writing and review of IND and BLAs.

This position is located in Cambridge, MA, reporting to the Chief Technical Operations Officer.

Voyager is internalizing the scientific development of most critical assays, but externalizes all GMP activities. Thus, the candidate will be required to travel, as needed, to CROs in US or overseas.

Responsibilities:

  • Lead overall analytical development and testing project plans for existing and envisioned projects
  • Develop analytical methodologies and strategies needed to progress products in the pipeline including method development, process support, formulation and stability support, product characterization and method qualifications
  • Partner with other Technical Operations functions (process development, external manufacturing and Quality) to enable aligned goals and achievement of deliverables
  • Manage and participate in tech transfer of analytical methods to CMO’s/CRO’s
  • As member of CMC team meeting, provide estimates for the resources, cost, timeline tasks, and alternative options to accomplish desired schedule
  • Coordinate the interaction of the CMC cross-functional projects among Voyager personnel, and between Voyager and the CROs.
  • Partner with External oversight team and work closely with CROs used to test GMP material, using site visits and frequent communication with CRO team members to update status of projects
  • Interact with program core teams to ensure alignment of CMC analytical development and testing plan with overall program strategy, and the requirements of pre-clinical and clinical teams
  • Monitor scope, milestones, dependencies, and costs associated with CRO project and the timelines for CRO deliverables.
  • Drive projects through project goals to ensure compliance to defined schedule.
  • Interact with finance to appraise them of changes in cost and assignment of work orders to specific functions and tasks
  • Create and maintain comprehensive risk management plan for product testing
  • Working with the CMC team, provide effective mitigation and escalation strategies for project risks and CMC issues.
  • Manage short and long-term analytical development and testing needs for projects and impact into supply of drug substance and drug product and communicate levels to internal project teams.
  • Develop and update standard internal CMC plans, based on process and historical data, to provide guidance on cost and Analytical Development FTEs required for new Development projects
  • Manage transition of CMC project from research to development and from early stage to late stage production at a CRO.
  • Strengthen and maintain relationships with key Voyager project team employees and outside vendors and suppliers of CMC services.
  • Ensure project teams adhere to company and departmental policies, procedures, and standards for storage of data related to product production
  • Develop and deliver scientific presentations, prepare clear and concise technical reports, participate in project teams, and contribute to regulatory filings
  • Execute all aspects of people leadership, including performance evaluations, mentorship, and ensure effective development plans for all employees

Requirements:

  • PhD or Masters in Virology, analytical chemistry, biotech, biochemistry or a related field
  • Minimum 8+ (with a PhD) or 15+ years (with an MS) of analytical development experience in industry
  • In-practice knowledge of the ICH for assay qualification and validation
  • Demonstrated ability to efficiently develop an assay from conception to a qualified/pre-validated state
  • Experience with bioassay development for biologics/vaccines/gene therapy
  • Experience managing outsourced analytical development
  • Strong project management skills
  • Candidate should be detail-oriented, self-motivated, goal driven, and should be able to work effectively on teams to progress projects.
  • Demonstrated ability to multi-task and be highly productive in a fluid and fast-paced environment
  • Experience leading teams of at least 6 people
  • Ability to write and communicate effectively with cross-functional teams

Preferred Skills:

  • Experience in developing methods and performing the analysis of AAV or other similar viral vectors
  • Strong expertise in bioassay development for viral vectors
  • Industrial experience and an understanding of the biologics/vaccines drug development process is desired
  • Experience leading assay development in support of approved BLAs
To apply, email careers@voyagertherapeutics.com

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Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Huntington’s disease, Friedreich’s ataxia, Alzheimer’s Disease and neuropathic pain.

We are seeking an experienced and highly motivated neurobiologist to contribute to our research team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in in vivo and ex vivo methods, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental execution and data analysis for research studies supporting cutting edge therapeutic programs and platform discovery research in neurodegenerative disease areas.   We are looking for a candidate with extensive prior experience in drug discovery in neurodegenerative diseases and with hands-on techniques in rodent in vivo studies, CNS tissue dissection, and downstream analysis (tissue sectioning, immunohistochemistry, RT-qPCR, western blot and ELISA). This position is located in Cambridge, MA and reports to a Senior Scientist.

Requirements:

  • A minimum of a Bachelor’s degree in Biology or related discipline with 5+ years of professional work experience or a Master’s degree with 2+ years of professional work experience in Biology or related discipline
  • Extensive hands-on experience in experimental execution and data analysis
  • Outstanding problem-solving skills
  • Ability to be highly productive in a fluid and fast-paced work environment
  • Hands-on experience with rodent handling, drug administration, tissue dissection and analysis
  • Experience with design, documentation and execution of experiments
  • Ability to independently analyze and present data to scientific team

Strongly Preferred:

  • Familiarity with stereotaxic brain injections
  • Working knowledge of rodent safety/tolerability assessments
  • Familiarity with molecular and biochemical methods, such as ELISA, western, and immunohistochemistry
  • Experience with participation on cross-functional therapeutic program teams
  • Experience within a start-up or small biotech environment
To apply, email careers@voyagertherapeutics.com

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Voyager Therapeutics is developing life-changing gene therapies for fatal and debilitating diseases of the central nervous system. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy, expressed RNA interference and neuroscience. Our management team has deep expertise and a track record of building exceptional life science companies.

Voyager Therapeutics seeks an experienced and highly motivated biologist to contribute to its research team at its facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in behavioral/system neuroscience, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work at the bench and be responsible for experimental execution and data analysis for research studies supporting therapeutic programs and platform discovery research.  The successful candidate will have extensive prior experience in drug discovery and in neurodegenerative diseases.  S/he will have extensive prior hands-on expertise in performing survival surgeries including stereotaxic or direct intraparenchymal injection, pharmacological administration, rodent (mouse and rat) behavioral testing, brain and tissue collection, and downstream analysis (RT-qPCR, western blot and ELISA).

Responsibilities:

  • Drive the planning strategies to include designing and executing rodent in vivo experiments: animal handling, test article dosing via various administration routes including stereotaxic surgeries
  • Performing behavioral assays of rodent models for various neurodegenerative diseases to assess motor and cognitive dysfunction
  • Performing perfusion, tissue dissection and collection
  • Conducting ex vivo tissue analysis (ELISA, western blot, RT-qPCR, etc.)
  • Performing data analyses and delivering data presentation to the research team
  • Ensuring maintenance of industry-quality records to provide documentation

Requirements:

  • A Bachelor’s Degree with a minimum of 8 years of experience, a Master’s Degree with a minimum of 5 years of experience, or a PhD with a minimum of 1-3 years of experience in neuroscience or related discipline is required
  • At least 5 years of hands-on experience with performing survival surgeries including stereotaxic or direct intraparenchymal injection, rodent (mouse and rat) behavioral testing to assess motor dysfunction
  • Outstanding problem-solving skills and ability to multi-task
  • Experience with relevant molecular biological techniques (i.e. (RT-qPCR, western blot and ELISA)
  • Self-motivated, able to work independently, highly organized with strong attention to detail
  • Experience in rodent pharmacology experiments and blood/tissue collection
  • Competency with database, spreadsheet and presentation applications (i.e. Excel, PowerPoint, Data entry systems, or similar)

Strongly Preferred:

  • Working knowledge with neurological disease models
  • Cross-functional communication skills highly preferred
  • Experience within a start-up or small biotech environment

1QC

To apply, email careers@voyagertherapeutics.com

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Voyager is seeking a highly motivated research associate scientist with significant experience and demonstrated success with rAAV vector production to join our research team.

This research associate scientist will contribute hands-on to manufacturing and QC of diverse, in-house research-grade rAAV vectors for in vitro and in vivo research studies.  In this role, the individual will participate in upstream and downstream processing of small- to medium-scale research-grade batches of rAAV vectors using multiple production systems, as well as QC of these batches. Since multiple novel AAV capsids will be evaluated, development of new production methods will be a key component of the work. This individual will play an important role assisting the head of the group in prioritizing and planning the vector production work and implementing the plan. This is an ideal position for an individual who is energetic and thrives in a team-oriented, fast-paced, and cross-disciplinary small biotech company environment. This role is located in Cambridge, MA.

Responsibilities

  • Produce rAAV vectors using triple transfection and baculovirus/sf9 systems including generation of baculovirus expression vectors (BEVs) and baculovirus infected insect cells (BIICs), and vector QC
  • Develop and optimize protocols for production of rAAV vectors using triple transfection and baculovirus/sf9 systems, especially for novel vectors
  • Identify and apply effective resolutions to any technical challenges during upstream and downstream processes and QC
  • Optimize multiple cell culture platforms for rAAV vector production including mammalian and insect cells
  • Ensure adequate use of electronic tracking system for documenting and tracking vector production requests, status and inventory

Requirements

  • B.S in a biological science or chemical engineering (vectorology or bioprocessing focus) with minimum of 2-3 years of subsequent research, vector manufacturing, or process development experience
  • A minimum of 2 years of relevant experience in the production of biologics with a focus on rAAV viral vectors, including familiarity with different rAAV production systems, especially triple transfection and baculovirus/sf9 systems
  • Excellent organizational skills and attention to detail
  • Strong commitment to accountability for completion of objectives in accordance with established plans
  • Ability to be highly productive and flexible in a fluid and fast-paced work environment
  • Ability to troubleshoot manufacturing issues and find timely solutions
  • Strong written and oral communication skills

Strongly Preferred

  • A minimum of 2 years of experience within a start-up or small biotech environment
  • Experience in downstream processing technologies
  • Experience and knowledge of biologics and/or gene therapy vector manufacturing

 #18KG

To apply, email careers@voyagertherapeutics.com

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Position Summary

The Director, Human Resources will play an important role in the Voyager organization.   This new role will focus on organizational development, employee development and culture within our fast growing organization.   This new leader will build and maintain strong relationships with Voyager leadership, and and will provide advice and support on talent management, employee relations, communications and longer-term organizational planning.   The Director will focus on developing and implementing programs which build core skills, accelerate learning, provide real-time feedback and improve cross-functional information sharing and engagement.   This position will lead all business partner work, and will develop a team who can effectively build and scale our organization, while maintaining the critical elements of our culture and identity.

Responsibilities

  • Build relationships with organizational leaders to understand evolving needs for critical HR programs that helps align needs and program priorities.
  • Develop strong, real-time talent management system which links our people to critical company goals, and provides frequent feedback on performance and opportunities to grow and learn
  • Act as coach and advisor to managers at all levels on effectively managing people.   Help design key training and development solutions that strengthen manager capabilities
  • Enhance company communication vehicles across the organization in a way that promotes culture, key learning, effective information sharing and skill building.   Develop effective means to communicate basic program requirements such as policies, tools & templates, etc.
  • Manage rollout of annual engagement survey and follow up with communication of results and design and implementation of key action plans to maintain positive results, improve in opportunity areas
  • Review and improve company communications on job requirements, career paths, recruiting postings to establish compelling descriptions of our work with clear expectations on performance success
  • Promote strong culture through review and design of key organizational processes, from onboarding through all areas of employee experience.   With team, improve and redesign processes to enhance effectiveness while keeping process simple and scalable
  • Develop short and long-term goals at each functional level, and design solutions which fit both broad organizational needs and functional-specific solutions
  • Work with HR Operations Manager to design and share key metrics on organizational performance and employees, including talent management, talent acquisition, compensation competitiveness, retention, and other areas

Experience and Skills Desired

  • Bachelor’s Degree required, advanced study in relevant field desirable
  • Minimum of 10 years of progressive HR experience in business partner roles, with broad generalist knowledge in employee relations, compensation, organizational development, training and talent acquisition.
  • Biotech or pharma industry experience required
  • Strong relationship building and coaching skills at all levels of the organization
  • Excellent project management and organizational skills
  • Solid business acumen, with ability to analyze data, manage budgets and measure results and effectiveness of programs
  • flexible, resourceful, and with a great sense of humor, ability to work effectively on multiple tasks on deadline and under pressure with grace and success
  • Strong communication skills, both as an effective writer and presenter of information
  • Strong interpersonal and problem-solving skills are required
To apply, email careers@voyagertherapeutics.com

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Director of Talent Acquisition

Voyager seeks its first Director of Talent Acquisition to lead our ongoing efforts to attract and retain outstanding talent in our fast-growing organization.  

The Director will manage current talent acquisition efforts while building processes, brand, team and strategy to insure longer-term success and alignment with key organizational goals.   This role will oversee the full recruiting cycle from planning through successful onboarding, and will help develop the Voyager recruiting process to continue to deliver strong candidates with an effective process and positive candidate experience.

Responsibilities

  • Lead the talent acquisition team, and manage staffing to support workforce needs.
  • Partner with business leaders to enhance current recruitment efforts and pipeline development. develop longer-range plans for recruiting readiness aligned with company’s plans
  • Develop effective recruitment strategy for each area of the organization, identifying current and future candidates from a variety of sourcing methods
  • Build competitive knowledge of gene therapy, neuroscience, both in industry and academic worlds,  and other key areas to accelerate sourcing of highly qualified talent for current and future needs.
  • Define Voyager recruitment process, establishing and training in best practices for sourcing, screening, interviewing, referencing and feedback, negotiation of offers, onboarding and all candidate interactions and communications
  • Enhance Voyager’s efforts on branding and messaging and develop plan for effective recruiting messaging with audiences including candidates and partners
  • Evolve company’s recruiting techniques to assess candidates on both skills and culture fit to maximize fast integration and likely retention.  Promotes company core values and importance of diversity and inclusion
  • Lead implementation of new applicant tracking system, train managers on Voyager process and use of new system and tools
  • Review and report on recruiting effectiveness using metrics which assess progress and success
  • Build relationships with key external partners for specialized staffing needs or for additional resourcing needed to attract and engage target candidates

Experience and requirements

  • Bachelor’s degree required, with 10+ years of recruiting experience, including some managing recruiters
  • Biotech work experience required, with demonstrated track record in recruitment
  • Highly organized, effectively multi-tasker who can build processes and organization
  • Excellent communicator and relationship builder who can develop talent, give effective feedback
  • Strong professional presentation who is a highly effective representative for Voyager
To apply, email careers@voyagertherapeutics.com

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Senior Scientist – Analytical Sciences Outsourcing

 Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases.  Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.

Voyager is seeking a highly motivated scientist to manage the Analytical Development and Testing conducted at External Contract Research Organizations (CROs). The qualified candidate will be responsible, in collaboration with Voyager’s Analytical Development and Quality, to oversee the qualification, transfer and execution of new state-of-the-art analytical methods to be used for release and characterization of Voyager’s clinical and commercial products at external CROs. Additionally, the individual will partner closely with Manufacturing to ensure constantly update status of lot release and any pending investigation or other issues requiring speedy resolution.

This position is located in Cambridge, MA, reporting to the Director, External Manufacturing & Supply. The candidate is required to travel, as needed, to CROs in US or overseas. Travel requirements will vary but may be up to 50%, as needed.

 

Primary responsibilities

  •  Develop external analytical development and testing project plans for existing and envisioned projects, with input from other Technical Operations functions (process development, analytical development, manufacturing and Quality)
  • Manage and participate in tech transfer of analytical methods to CMO’s/CRO’s
  • Develop analytical methodologies and strategies needed to progress products in the pipeline including method development, process support, formulation and stability support, product characterization and method qualifications
  • As member of CMC team meeting, provide estimates for the resources, cost, timeline tasks, and alternative options to accomplish desired schedule
  • Coordinate the interaction of the CMC cross-functional projects among Voyager personnel, and between Voyager and the CROs.
  • Work closely with CROs used to test GMP material, using site visits and frequent communication with CRO team members to update status of projects
  • Interact with program core teams to ensure alignment of CMC analytical development and testing plan with overall program strategy, and the requirements of pre-clinical and clinical teams
  • Monitor scope, milestones, dependencies, and costs associated with CRO project and the timelines for CRO deliverables.
  • Drive projects through project goals to ensure compliance to defined schedule.
  • Interact with finance to appraise them of changes in cost and assignment of work orders to specific functions and tasks
  • Create and maintain comprehensive risk management plan for product testing
  • Working with the CMC team, provide effective mitigation and escalation strategies for project risks and CMC issues.
  • Manage short and long-term analytical development and testing needs for projects and impact into supply of drug substance and drug product and communicate levels to internal project teams.
  • Develop and update standard external CMC plans, based on process and historical data, to provide guidance on cost and FTEs required to manage and produce GMP material for new Development projects
  • Manage transition of CMC project from research to development and from early stage to late stage production at a CRO.
  • Strengthen and maintain relationships with key Voyager project team employees and outside vendors and suppliers of CMC services.
  • Ensure project teams adhere to company and departmental policies, procedures, and standards for storage of data related to product production
  • Develop and deliver scientific presentations, prepare clear and concise technical reports, participate in project teams, and contribute to regulatory filings

Minimum Qualifications

  • PhD or Masters in analytical chemistry, biotech, biochemistry or a related field
  • Minimum 5+ (with a PhD) or 15+ years (with an MS) of analytical development experience in industry
  • In-practice knowledge of the ICH for assay qualification and validation
  • Demonstrated ability to efficiently develop an assay from conception to a qualified/pre-validated state
  • Experience with bioassay development for biologics/vaccines/gene therapy
  • Experience managing outsourced analytical development
  • Strong project management skills
  • Candidate should be detail-oriented, self-motivated, goal driven, and should be able to work effectively on teams to progress projects.
  • Demonstrated ability to multi-task and be highly productive in a fluid and fast-paced environment
  • Ability to write and communicate effectively with cross-functional teams

Preferred Qualifications

  • Experience in developing methods and performing the analysis of AAV or other similar viral vectors
  • Industrial experience and an understanding of the biologics drug development process is desired.
To apply, email careers@voyagertherapeutics.com

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Director, External Manufacturing and Supply

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes is central for establishing successful gene therapy applications. Voyager is seeking Director, External Manufacturing and Supply who will manage multiple CMC projects with CMOs, as well as the overall Supply Chain network for clinical material distribution.

This role leads external manufacturing function at Voyager and assists the cross-functional interaction among the internal development team (process development, analytical development and Quality teams) and the CMO, particularly being responsible for the interaction with the CMO project managers.  S/he develops CMC project budgets, timelines, and risk assessments, and is responsible for performance against these parameters.  The individual actively monitors and reports on project status, the financial status of the work within the CMOs, interacts regularly with the program core team and other functions as necessary to communicate the risks and decisions required and highlights assumptions associated with CMC timelines.

The role reports into the Voyager Chief Technical Operations Officer and supervises Manufacturing Sciences engineers in charge of CMO oversight. This position is located in Cambridge, MA and will travel 20-50% ( U.S. / Int’l ).

Responsibilities

  • Develops and implements overall strategy for External Manufacturing and Supply, in collaboration with other Technical Operations functions
  • Lead the development of external CMC project plans for existing and envisioned projects, with input from other Technical Operations functions (process development, analytical development, and Quality)
  • Manages overall External Manufacturing budget and spent, carefully balancing risk and cost
  • Responsible for external GMP warehouse and storage facilities for cell lines and virus banks, DS and DP, and the overall Supply Chain network for clinical trial material distribution
  • As member of CMC team meeting, provide estimates for the resources, cost, timeline tasks, and alternative options to accomplish desired schedule
  • Coordinate the interaction of the CMC cross-functional projects among Voyager personnel, and between Voyager and the CMOs.
  • Work closely with CMOs used to produce GMP material, using site visits and frequent communication with CMO team members to update status of CMC project
  • Interact with program core teams to ensure alignment of CMC plan with overall program strategy, and the requirements of pre-clinical and clinical teams
  • Monitor scope, milestones, dependencies, and costs associated with CMO project and the timelines for CMO deliverables.
  • Drive projects through project goals to ensure compliance to defined schedule.
  • Interact with finance to appraise them of changes in cost and assignment of work orders to specific functions and tasks
  • Create and maintain comprehensive risk management plan for product production
  • Working with the CMC team, provide effective mitigation and escalation strategies for project risks and CMC issues.
  • Manage short and long-term project commitments to supply of drug substance and drug product and communicate levels to internal project teams.
  • Develop and update standard external CMC plans, based on process and historical data, to provide guidance on cost and FTEs required to manage and produce GMP material for new Development projects
  • Manage transition of CMC project from research to development and from early stage to late stage production at a CMO.
  • Strengthen and maintain relationships with key Voyager project team employees and outside vendors and suppliers of CMC services.
  • Assist in coordinating key vendor and supplier evaluations, particularly those supplying services related to raw material supply, product manufacturing, release, storage, and characterization.
  • Ensure project teams adhere to company and departmental policies, procedures, and standards for storage of data related to product production.

Qualifications

  • Minimum PhD in Chemical Engineering with 10+ experience with processes to make biologics, viral vectors or vaccines, or BS\MS degree in Chemical Engineering with 20+ years of experience with processes making biologics, viral vectors or vaccines
  • Experience with planning and managing CMC aspects of biopharmaceutical development
  • Experience in process development and process transfer, focused on biologics or proteins, viral vectors or vaccines
  • Experience in CMO search, selection and management
  • Experience as person in plant (PIP) for production of biopharmaceutical products
  • Ability to travel ( U.S./ Int’l ) 25-50% of time, particularly when production campaigns are being done
  • Has demonstrated the ability to organize external resources to maximize quality and efficiency. Maintains an overview of the entire process when planning a project, setting both short and long-term goals.
  • Works effectively aligning actions to project targets, milestones, and priorities.
  • Excellent communication skills, with the ability to provide clear and audience-focused descriptions of CMC tasks and issues, and proposed solutions to schedule challenges, all done in an open and honest manner.
  • Able to achieve goals in a timely manner, despite obstacles, by prioritizing tasks and building in contingency planning. Results oriented and demonstrates a focus on getting (business) results.
  • Demonstrated ability to facilitate project team meetings, enhance cross-functional communication, support decision making, influence outcomes, and ensure alignment among internal (and sometimes external) stakeholders.
  • Familiar with current issues and Regulatory requirements related to manufacturing using single use equipment for drug substance and drug product production
  • Familiar with trends and developments in the gene therapy field and able to translate those developments into specific business advantages and risks related to production.
  • Proficiency with Microsoft Office suite (e.g. Word, Excel, PowerPoint, Project, Outlook).
To apply, email careers@voyagertherapeutics.com

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Director, Patient Advocacy

Voyager Therapeutics is looking for a creative, energetic, compassionate, and clinically oriented person to manage programs, communications, and organizational relationships in patient advocacy.  This individual should be committed to supporting active programs and clinical development efforts within Voyager by building collaborative relationships with foundations and patient organizations. The role will report directly to the CMO and will work closely with multidisciplinary teams.

 The successful incumbent will establish and maintain strong relationships with key patient organizations that will provide:

  • Insight into unmet clinical needs, attitudes toward and understanding of gene therapy and route administration.A keen understanding of patient experience of current medical care including costs and barriers to treatment
  • A collaborative approach to implementation of Voyager’s preclinical and clinical stage programs, and potential commercialized products
  • An understanding of patient experiences broadly and specific perspectives on Voyager clinical studies.
  • Develop and implement a patient advocacy strategy that will support all stages of development in collaboration with key functions including clinical development, regulatory, commercial, medical affairs, market research and communications teams.
  • Develop and implement educational and outreach programs to inform and engage Voyager staff and build strong working relationships with patient groups across the organization.

Responsibilities

Develop and maintain strong relationships with key patient groups, foundations, and non-profit organizations, in the US and targeted international markets.

  • Work with relevant Voyager teams to build partnerships and initiatives with these organizations to support development efforts. These may include:
    • Epidemiology studies
    • Natural history studies and patient registries
    • Biomarker development
    • Recruitment and retention efforts in clinical studies
    • Product profile development
    • Education and communications strategy
    • Patient advisory board planning and implementation
  • Recruit and develop Patient/care giver, opinion leaders to lead and build patient support groups and communities both online and off-line.
  • Contribute patient/provider perspectives in preparation and planning of clinical studies, regulatory efforts, and other relevant initiatives within Voyager.
  • Build involvement of organizations in regulatory and advocacy efforts as appropriate.
  • Maintain and expand Voyager’s network of patient opinion leaders.
  • Coordinate internal Voyager events and education efforts regarding disease knowledge and patient perspective.
  • Maintain outreach efforts to connect with new organizations, including those relevant to new and/or potential programs and to broader areas relevant to Voyager’s mission.
  • Manage company commitment to organizations, including event sponsorships, employee involvement, and communications around ongoing organizational initiatives.

 Minimum Requirements

  • BA/BS degree in science or health related area. Degrees in medicine (MD), nursing (RN), public health (MPH), relevant advanced degree (PharmD, PhD), or significant relevant experience as a genetic counselor or similar medical professional are strongly preferred.
  • Minimum of 7 years in the pharmaceutical, biotechnology or healthcare industry required, with demonstrated ability to cultivate and manage strong relationships with key internal and external stakeholders.
  • Excellent oral and written English communication skills. 
  • Demonstrated strategic and critical thinking skills.
  • Ability to interact externally and internally across functions to support the clinical, scientific, and business strategy.
  • Ability to exercise judgment and address complex problems to create solutions across multiple stakeholders with varying interests and perspectives.

 

 

To apply, email careers@voyagertherapeutics.com

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To apply or learn more about career opportunities at Voyager Therapeutics, please email careers@voyagertherapeutics.com.

Note to Employment Agencies: Please do not forward agency resumes. Voyager Therapeutics is not responsible for any fees related to resumes that are unsolicited and out of executed contracts.

Voyager Therapeutics will only accept job applications from candidates who are properly documented with authorization to work in the United States.

Equal Opportunity Employer M/F/D/V